Project Grant R21HG013393
- The University of California, Los Angeles (UCLA) received a $433,125 Project Grant award under the Biomedical Research and Research Training program (CFDA 93.859) from the National Institute of General Medical Sciences (NIGMS). The goal of this five-year project is to thoroughly and mechanistically characterize the effects of genomic variation on genome function and phenotypes. The project will adopt a multidisciplinary approach that integrates cutting-edge technologies, including...
- This $1,089,491 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to develop novel statistical methods, computational algorithms, and user-friendly software to study individual health trajectories relevant to disease onset and progression for large, diverse healthcare datasets like electronic medical records and biobanks. The research, to be conducted by the University of...
- The National Science Foundation Division of Information and Intelligent Systems awarded a $1,199,873 Project Grant to the University of California, Los Angeles to support the project "MEDIUM: CAUSAL INFERENCE IN BIOBANKS: LEVERAGING GENETICS TO INFER CAUSAL RELATIONSHIPS USING ELECTRONIC HEALTH RECORDS" from September 1, 2021 through August 31, 2025. The grant funding will support research and education activities under the official federal grant program "Computer and...
- This $780,113 Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) aims to develop methods for quantifying and correcting biases in the genetic study of complex traits. Specifically, the research will: Create a comprehensive simulation framework to model realistic intergenerational dynamics and understand genetic transmission across generations. This will help correct biases in current methodologies used to study genetic architecture....
- The University of California, Los Angeles (UCLA) was awarded a $415,876 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) by the National Institutes of Health Office of the Director, with a performance period from August 1, 2024 to July 31, 2026. The purpose of this grant is to optimize and utilize a novel five-dimensional (5D) magnetic resonance spectroscopic imaging (MRSI) technique called "ROSE-JRESI" and three-dimensional myelin water imaging (MWI) to study...
- This federal Project Grant award of $267,098 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, Los Angeles (UCLA) on August 1, 2025. The project, titled "Learning Gene Regulatory Networks under Latent Confounding and Data Dependence," aims to develop statistical methods to infer the structure of gene regulatory networks (GRNs) and identify direct causes of...
- The National Institutes of Health (NIH), through the Medical Library Assistance federal grant program (CFDA 93.879), awarded a $249,000 Project Grant to The Regents of the University of California, San Francisco (UCSF) to develop a data science framework for transforming electronic health records (EHRs) into real-world evidence. The project aims to integrate data from randomized controlled trials (RCTs) and EHRs to better emulate RCTs using EHR data and measure the same effects seen in the...
- This $696,824 federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports research at the University of North Carolina at Chapel Hill (UNC-CH) to develop robust and interpretable multi-modal AI/ML models for precision medicine. The project aims to address key challenges in integrating complex, heterogeneous biomedical data...
- The University of California, San Francisco (UCSF) was awarded a $1,453,500 Project Grant by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The funding will support the development of a novel, physiologically-focused approach to train multi-modal artificial intelligence (AI) algorithms for medical applications. Specifically, the project aims to create a new deep neural network architecture that can accept and learn from multiple...
- The National Human Genome Research Institute (NHGRI), under the CFDA program 93.172 Human Genome Research, awarded a $1,100,866 Project Grant to the Icahn School of Medicine at Mount Sinai. The grant, awarded on April 8, 2025, is to develop new methods using deep learning to predict disease risk for individuals harboring rare monogenic risk alleles. The goal is to refine the accuracy of genetic diagnostics and increase the clinical usefulness of genetic information. The project will leverage...
The University of California, Los Angeles (UCLA) has been awarded a $428,448 Project Grant under the National Institutes of Health (NIH) Human Genome Research program (CFDA 93.172). The award, with a project period from September 2023 to August 2025, will fund the development of a novel contrastive learning method to identify biologically and clinically relevant disease subtypes from electronic health record (EHR) data. The goal is to advance precision medicine by uncovering meaningful heterogeneity across common complex diseases like obesity, diabetes, and psychiatric disorders. The research will leverage the large-scale EHR data in the All of Us database, with plans to replicate findings in three external EHR cohorts. Additionally, the project will develop a domain generalization framework to ensure the identified disease subtypes are generalizable across demographic factors like location, ancestry, and race. This work aims to enable equitable integration of predictive models into healthcare systems.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $428.4k | 9/22/23 |