The Children's Hospital Corporation, doing business as Boston Children's Hospital, was awarded a $223,224 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) from the National Institute of Child Health and Human Development. The grant will fund a 2-year study to investigate the relationship between altered brain connectivity, developmental outcomes, and executive function in patients with congenital heart disease (CHD). The research aims to differentiate the impacts of prenatal factors versus postnatal environmental factors on brain structure and cognitive outcomes in CHD. The study will leverage MRI data and neurodevelopmental assessments from two cohorts of CHD patients - infants with pre-operative scans and 22-month outcomes, as well as adults aged 26-34 with MRI and cognitive testing. The overarching goal is to identify early predictors of executive function impairment in CHD to inform appropriate interventions and improve long-term neurodevelopmental outcomes.
Generated 1/28/25, 7:38 AM