Project Grant R21GM159202
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will support the development of a novel method for modifying cellular signaling pathways using implanted electronic devices. The $10,000.00 award to the Regents of the University of California, San Francisco (UCSF) aims to create a new tool for studying complex cellular behaviors by interfacing electronic circuits with molecular networks within cells. The 2-year project, running from March...
- This federal Project Grant award of $1,968,575.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is focused on developing computational approaches and machine learning methods to predict DNA-binding specificities for transcription factor proteins and the functional effects of genetic variants within proteins. The overarching goal is to gain a predictive understanding of proteins, their interactions,...
- This Project Grant award from the National Science Foundation (CFDA 47.041 - Engineering) totaling $1,400,000 aims to advance the manufacturing of ultra-high-density, DNA-enabled nanoelectronics systems. The key goals are to: Develop scalable methods for obtaining high-purity carbon nanotubes, self-aligned single-molecule junctions, and hybrid DNA nanostructures. Establish reliable processes for integrating bottom-up and top-down architectures using field-driven directed assembly and...
- This federal Project Grant award of $349,566 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology for high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The key products and services delivered through this award include: Integration of innovative technologies...
- This $1,399,500 Project Grant award from the National Institutes of Health's Trans-NIH Research Support program (CFDA 93.310) will fund research at the University of Wisconsin - Madison to develop "cellular radio" circuits that can be used to visualize, probe, and perturb the dynamic protein activity in individual cells. The project aims to create genetically-engineered circuits that generate a frequency-modulated, barcoded fluorescent signal to track how the internal state of cells...
- This $448,150 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a DNA-based toolbox for the rapid and precise modulation of cell membrane protein-protein interactions (PPIs). The goal is to establish a modular approach using antibodies and aptamers to enable targeted DNA barcoding of cell membrane proteins, particularly receptor tyrosine kinases. This will allow for the controlled stabilization of specific PPI pairs on living...
- This $418,043 Project Grant, awarded by the National Institute of Biomedical Imaging and Bioengineering (CFDA 93.286: Discovery and Applied Research for Technological Innovations to Improve Human Health), is funding the development of a self-tunable mRNA gene circuit to precisely control cellular protein levels. The goal is to create a modular, self-adjusting mRNA circuit that can accurately regulate target protein concentrations in cells, addressing challenges with maintaining optimal protein...
- This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
- The National Institute of General Medical Sciences (NIGMS) has awarded a $389,653 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Research Foundation for the State University of New York (RF-SUNY), doing business as Rf-SUNY At The University At Albany. This 5-year project, starting on January 1, 2025, aims to develop a transdisciplinary research program centered around AI-supported biosensing and precision therapeutics using DNA nanotechnology and...
- The U.S. National Institute of General Medical Sciences (NIGMS), through the Biomedical Research and Research Training federal grant program (CFDA 93.859), awarded a $432,834 Project Grant to the Board of Regents of the University of Nebraska on April 15, 2025. The grant supports the development of an "enzyme-free, label-free quantitative microarray technology" to detect and quantify target nucleic acids, such as microRNA, with high sensitivity down to the attomolar (10^-18 M) range....
The Project Grant award of $427,079.00, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop DNA-based transistors capable of precisely controlling cellular functions. The research project, titled "DNA Transistors for Cellular Programming," focuses on creating synthetic receptors that can respond to specific DNA sequences, enabling control over cellular activities both externally and internally. The key products/services to be delivered include: 1) Engineering extracellular DNA transistors for signal interpretation, and 2) Developing intracellular DNA transistors to regulate cellular processes. This groundbreaking approach has the potential to advance disease treatment and tissue engineering by offering a highly versatile and programmable method for controlling cellular functions with high specificity. The award period runs from Aug 1, 2025 to Jul 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.1k | 7/24/25 |