The National Institute of General Medical Sciences (NIGMS) awarded a $384,896 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Missouri System. The award will fund research to engineer peptide-based biomodulatory materials that can serve as translational platform technologies for various biomedical applications. Specific objectives include using computational and experimental techniques to develop design rules for micellar...
The National Institute of General Medical Sciences (NIGMS) awarded a $752,456 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Pittsburgh. The grant, effective September 1, 2024 through July 31, 2029, supports the development and application of innovative, user-friendly computational technologies for identifying new bioactive small molecules and improving their pharmacological properties. Key focus areas include creating a database of...
The National Institute of General Medical Sciences (NIGMS) awarded a $221,448 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Massachusetts Institute of Technology (MIT) to develop peptide catalysts for stereo- and site-selective C-C bond formation reactions. The research leverages automated fast-flow peptide synthesis and machine learning to design peptide catalysts containing non-natural residues that can achieve precise control over reaction...
This $368,110 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to study the structures and properties of key enzymatic intermediates involved in oxygenase chemistry. The research aims to develop peptide-based synthetic models that can mimic the active sites and reactivity of non-heme iron and copper oxygenases, which are critical for metabolism, natural product...
The National Institute of General Medical Sciences (NIGMS) awarded a $401,233 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) federal grant program to Duke University, effective August 1, 2025 through May 31, 2030. The grant supports the development of new catalytic selective amination methods and aminofunctionalization cascades to expedite the synthesis and study of structurally diverse, nitrogen-containing molecules as probes and leads for advancing the...
The National Institute of General Medical Sciences (NIGMS) awarded a $468,872 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, Los Angeles (UCLA) on May 1, 2025. The grant supports research focused on exploiting the unique properties of perfluorination to enhance therapeutics, diagnostics, and create new chemical tools. Specifically, the research aims to: Develop cyclophane host molecules that can recognize perfluorinated...
This Project Grant award of $350,000.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop an artificial intelligence-based platform for optimizing peptide-based drug candidates. The key products or services to be delivered include: Methods for encoding non-canonical amino acids and cyclic peptides to enable high-performance machine learning on commercial peptide sequence, activity, stability, and...
The National Institute of General Medical Sciences (NIGMS) awarded a $216,906 Project Grant to The Regents of the University of Colorado, doing business as the University of Colorado Office of Contracts and Grants Division, to conduct research on the "Evolution of Novel Metabolic Pathways" under CFDA Program 93.859 - Biomedical Research and Research Training. The funding will support the University's efforts to study how organisms can evolve new metabolic pathways to access new...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $585,000 in funding to the University of Texas at Dallas (UTD) for the period of August 1, 2025 to May 31, 2030. The grant supports two key objectives: Developing innovative strategies and platforms for discovering 'natural product'-like macrocyclic peptides as potent and selective modulators of biomolecular interactions. This...
The National Institute of General Medical Sciences (NIGMS) awarded a $427,571 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The award, which runs from January 15, 2025 to December 31, 2029, will support research to uncover the molecular determinants of cellular identity and the regulation of chromatin states across the cell cycle. Specifically, the...