The National Eye Institute (NEI), under the CFDA Program 93.867 Vision Research, awarded a $228,009 Project Grant (R21EY035454) to the Regents of the University of Minnesota. The grant funds a 2-year exploratory research project to assess two mechanistically differentiated approaches to inhibit the STING protein as a potential treatment for diabetic retinopathy (DR). The first aim is to evaluate small molecule-induced STING degradation using proteolysis-targeting chimeras (PROTACs), an innovative strategy unexplored in the eye. The second aim is to develop bifunctional small molecule probes that simultaneously agonize PPAR-alpha (for neuroprotection) and inhibit STING (for retinal vascular homeostasis and inflammation) to explore the benefits of polypharmacology in retinal disease. This research is expected to provide foundational data to enable proof-of-concept for these new therapeutic approaches in ocular contexts, advance understanding of STING biology and its therapeutic utility in DR and related diseases, and yield new compounds for further biological and translational initiatives.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $228.0k | 8/29/24 |