Project Grant R21ES036706

Award Date 6/24/25
Completion Date 6/13/27
Dollars Obligated $410K
Federal Grant Program
93.113
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, provides $567,093 to The Regents of the University of California, Berkeley to conduct research on the impact of wildfire exposure on the human methylome and health. The key objectives of this 2-year project are to: 1) develop comprehensive wildfire exposure assessments for a cohort of 5,000 adults in Northern California, 2) collect...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) Federal Grant Program provides $158,548 to the University of North Carolina at Chapel Hill to characterize the structural and functional changes of the respiratory microbiota and metabolome in response to wood smoke exposure. The key objectives are to identify the mechanisms by which the respiratory microbiome and its metabolites modulate the host response to...
This $332,562 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, supports the development of a hyperlocal temperature model covering the contiguous United States from 2000-2020. The model will use satellite data, land use features, and elevation to predict daily temperatures at the 30m road segment level. This hyperlocal temperature data will then be used to identify urban heat islands, hot and cold...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program provides $795,848 to the University of California, Davis to investigate the impacts of prenatal wildfire smoke exposure on maternal immune dysregulation, epigenetic changes in children, and associated child neurodevelopmental and behavioral outcomes. The 5-year study aims to enhance understanding of the immunologic and epigenetic...
This Project Grant award, with a total funding amount of $409,750, was provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program. The goal of the research is to gain a comprehensive understanding of how the transformation of metal oxide nanomaterials in wildland-urban interface (WUI) fires impacts their toxicity and ability to induce congenital heart defects. The research involves collecting and analyzing WUI...
This Project Grant award from the National Science Foundation's Geosciences Program (CFDA 47.050) provides $180,000 to conduct research on wildfire-generated nanoparticles and their impact on human health and the environment. The research aims to: 1) determine how temperature, composition of combustible materials, and soil composition influence the metal chemistry of fine particulate matter; 2) identify the mineralogy, metal associations, and morphology of these particles; and 3) examine how...
This R21 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program provides $433,950 to the University of California, Davis to study the impact of wildfire smoke exposure on lung injury and disease in pediatric populations. The key objectives are to: 1) Define the contribution of age on the toxicity of wood smoke particles in respiratory and alveolar epithelium, 2) Investigate the effect of early life wood...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program provides $728,408 to investigate novel genetic variants that confer susceptibility to pesticide-induced Parkinson's disease. The research aims to biologically validate candidate gene variants associated with increased susceptibility, using human induced pluripotent stem cell-derived neuronal cultures and a mouse model of paraquat-induced...
This $595,043 Project Grant award was provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program. The grant titled "PURE-CLIMATE: IDENTIFYING AND ADAPTING TO CLIMATE CHANGE AS A MODIFIABLE RISK FACTOR FOR HUMAN HEALTH" will leverage the existing infrastructure and data of the Prospective Urban and Rural Epidemiology (PURE) study to establish a global study on the impacts of climate change on human...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) Federal Grant Program provides $676,077 to Colorado State University (CSU) to study the impacts of fine particulate matter (PM2.5) air pollution on cardiovascular and respiratory health outcomes. The key products and services being delivered under this award include: Deploying a national network to measure the oxidative potential of PM2.5 samples, which...

This Project Grant award, with a total funding amount of $409,687.00 and an award date of June 24, 2025, was provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) Federal Grant Program.

The grant aims to assess the impact of wildfire smoke and heat on cognition, mood, and the human metabolome in a vulnerable older population, specifically those with Parkinson's disease (PD). The research will leverage a large case-control study of approximately 1,000 PD patients and 1,000 community controls, analyzing comprehensive data on cognitive status, depressive symptoms, and residential histories. Advanced modeling techniques and metabolomic analysis will be used to explore the biological pathways underlying the effects of wildfire smoke and heat exposure on cognitive decline and mental health in this population. The findings have the potential to shed light on metabolomic features and pathways that influence susceptibility or resilience to these environmental factors in older adults.

Generated 7/15/25, 4:34 AM