This federal Project Grant award under the Environmental Health (CFDA 93.113) program, awarded by the National Institute of Environmental Health Sciences (NIEHS), provides $244,750 to investigate the role of the ELF1 protein in the transcription-coupled nucleotide excision repair (TC-NER) process. The research aims to elucidate the molecular mechanisms by which ELF1 recruits the TFIIH repair complex to RNA polymerase II, including the potential regulatory role of ELF1 phosphorylation. The grant supports a collaborative effort between the lead institution, Washington State University, and a sub-award to the University of California, San Diego to conduct biochemical and structural studies on the ELF1 C-terminal domain interactions. Findings from this research are expected to enhance understanding of how TC-NER is regulated and its importance for maintaining genome stability and mitigating environmental health risks.
Generated 3/4/25, 7:14 AM