Project Grant R21ES035485

Award Date 7/10/24
Completion Date 6/30/26
Dollars Obligated $239K
Federal Grant Program
93.113
Assistance Type
Project Grant
Place of Performance
Hamden, CT 06511, USA
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This federal Project Grant award of $238,995 from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program will fund a study to investigate the potential relationship between maternal exposure to ambient air pollution during pregnancy and the risk of cerebral palsy (CP) in children.

The study aims to use records from the California Department of Developmental Services to identify approximately 10,000 CP cases born in California between 2000-2015, and select a population-based control group of ~1.6 million births. The research team will apply a novel land-use-regression model to estimate daily gestational exposures to three major air pollutants (PM2.5, NO2, O3) at a high spatial resolution across California. They will then analyze the associations between these maternal air pollution exposures and CP risk, as well as explore potential mediating factors such as pregnancy complications or adverse birth outcomes. Additionally, the study will examine whether racial/social disparities in CP prevalence may be explained by environmental disparities in air pollution exposure.

The grant includes a sub-award to the University of California, Berkeley, where Dr. Su will develop annual-average air pollution exposure surfaces to support the epidemiological analysis and interpretation of the results. The study is expected to run from the award date of July 2024 through June 2026.

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