Project Grant R21ES030175

This Cooperative Agreement award, funded by the National Institute on Aging (CFDA 93.866 Aging Research), provides $2,533,483 to The Trustees of Columbia University in the City of New York to conduct a longitudinal study examining the impact of environmental toxicants on the risk of Alzheimer's disease (AD) and AD-related dementias (ADRD) in individuals with prediabetes and type 2 diabetes. The key products and services to be delivered under this award include: (A) longitudinal untargeted...

The U.S. National Institute of Environmental Health Sciences (NIEHS) awarded a $728,408 Project Grant under the Environmental Health federal grant program (CFDA 93.113) to the J. David Gladstone Institutes. The grant aims to biologically validate novel genetic variants associated with increased susceptibility to pesticide-induced Parkinson's disease. The research involves using human induced pluripotent stem cell-derived dopaminergic neuronal cultures and a mouse model of paraquat-induced...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $984,000 Cooperative Agreement (Award ID: U01DK140936) to the University of Chicago under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The purpose of this 5-year project is to conduct a cross-sectional and longitudinal study of gut microbiota in Parkinson's disease patients. The research aims to gain a better understanding of the role of gut dysbiosis in the...

This $483,000 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research at the University of California, Davis to investigate how chronic exposure to traffic-related air pollution (TRAP) may exacerbate metabolic disorders such as obesity and diabetes. The research team will leverage a unique animal exposure model to TRAP collected from a major freeway tunnel system to study the mechanisms by...

This federal Project Grant award of $318,710, awarded on September 18, 2024 by the National Institute of Environmental Health Sciences (NIEHS) under the Medical Library Assistance (CFDA 93.879) program, aims to develop an AI-empowered wearable multimodal sensor system for the non-invasive monitoring of Parkinson's disease (PD). The key objectives of this grant are to: 1) Develop computational methods to identify PD-specific biomarkers from multi-omics data and optimize their selection for a...

This $684,451 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports comprehensive research to advance understanding and treatment of Parkinson's disease (PD). The project aims to: Identify PD progression subtypes through integrative modeling of longitudinal clinical, transcriptomic, and neuroimaging data from the Parkinson's Progression...

This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), aims to identify and refine novel retinal biomarkers of prodromal Parkinson's disease (PD) that appear before the onset of motor symptoms. The $178,376 award, spanning August 1, 2025 to July 14, 2027, supports a comprehensive research plan with two key objectives: In a mouse model of PD, the research will use advanced in vivo retinal imaging and functional assays,...

This Cooperative Agreement award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will establish a consortium to study gut-brain communication in Parkinson's disease (PD). The $399,174 award will support the participation of PD patients and healthy controls in a registry, including in-depth phenotyping of clinical symptoms, gastrointestinal function, and...

The Department of the Army Medical Command awarded a $3.2 million Project Grant to The Trustees of Columbia University in New York, New York to support research titled "NOVEL EXPOSOMICS AND EXTRACELLULAR VESICLE BIOMARKERS TO UNRAVEL GENE - ENVIRONMENT INTERACTIONS AND MECHANISMS OF NEURODEGENERATION IN PARKINSON'S DISEASE." The grant period runs from September 1, 2022 to August 31, 2025. The funding supports research under the Military Medical Research and Development program (CFDA...

This Project Grant award of $171,064.00 from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program supports research to investigate how polychlorinated biphenyls (PCBs) alter the communication between adipocytes (fat cells) and macrophages (immune cells) in adipose tissue. The research aims to uncover the mechanisms by which PCB exposure disrupts adipose tissue function and contributes to metabolic disorders like...