Project Grant R21EB037846
- This federal Project Grant award of $388,000 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Northeastern University. The research aims to develop and validate a new class of engineered macrophages capable of tracking and modulating inflammation in vivo using multi-modal imaging techniques including ultrasound, MRI, and optical imaging. The project will establish a novel framework for...
- This $616,897 Project Grant was awarded on August 8, 2025 by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant supports the development of synthetic compartments that can insulate and sequester signaling components to rewire inflammatory signaling and restore immune cell function. Key objectives include insulating and shutting down components of...
- This federal Project Grant award, valued at $231,934.00, was provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant supports the development of a new modular platform technology that mimics lymph nodes to improve the engineering of T cells for cellular immunotherapy. The funded research aims to create biomimetic scaffolds that can...
- This Project Grant award of $390,000.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to improve the understanding of tissue-resident macrophage biology in vivo. The awardee, The Medical College of Wisconsin, Inc., will utilize a novel small vertebrate model, Danionella cerebrum, to systematically analyze the ontogeny, kinetics, and function of tissue-resident macrophages during homeostasis,...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) is funding research to investigate the role of mechanical cues in the extracellular matrix in regulating monocyte inflammation. The $406,250 award, which runs from January 1, 2025 to December 31, 2029, will support the development of human stem cell-based culture systems to study monocyte mechanobiology, the investigation of mechanical...
- This $438,900 Project Grant was awarded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant funds research to develop a "three-cell (T-NK-macrophage) immunotherapy system" using chimeric antigen receptor (CAR) and synthetic cytokine receptor (SCR) technologies. The primary goal is to engineer the three immune cell types to function...
- This $300,000 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will support research by the University of Delaware to decipher and manipulate the role of histone lactylation in controlling macrophage immune cell behavior. The project aims to create precision synthetic biology tools that can add or remove lactylation marks on DNA-packaging proteins, enabling a better understanding of how lactylation affects macrophage polarization between...
- This $393,750.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund a 5-year research project to explore the fundamental cellular mechanisms driving cellular senescence in macrophages. The key objectives of this research project are to gain a deeper understanding of the cellular and molecular mechanisms underlying senescent macrophage biology. This includes investigating the roles...
- The federal Project Grant award of $673,600.00 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop an RNA-based sensor that can detect changes in both mRNA and miRNA within living cells and mouse models. The objective is to create a programmable, synthetic biology tool that can identify diseased cells based on their RNA profiles and trigger...
- The federal Project Grant award for $191,300 was provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286). The award supports a 4-year research program led by Dr. Thomas C. Binns, MD at Yale University to study the interactions between polymeric nanoparticles and phagocyte cell subpopulations in both healthy and disease states, with the...
This Project Grant award of $621,158 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program, supports research to create a "human macrophage design toolkit" for engineering therapeutic macrophages. The goal is to elucidate the biological and gene circuit design principles needed to engineer macrophages that can suppress inflammatory cytokine secretion or induce anti-inflammatory cytokine secretion in inflamed tissues. The research is being conducted by Rutgers, The State University of New Jersey, and is expected to be completed by July 31, 2028. This work aims to address knowledge gaps in understanding how to engineer synthetic gene circuits that function robustly in human macrophages, a key step in advancing genetically engineered immune cell therapies for a wide range of complex diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $621.2k | 7/31/25 |