Project Grant R21EB037399
- This $576,493.00 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) aims to develop sophisticated, self-calibrating near-infrared fluorescent probes that can quantitatively assess microviscosity variations and monitor protein misfolding/aggregation within live cells. The probes are designed to have enhanced water solubility, stability, and cell permeability to maximize biocompatibility and selectivity for detecting viscosity changes and protein...
- This federal Cooperative Agreement award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $266,736.00 to the Mayo Clinic for a project focused on "Assay Validation of Cell-Free DNA Amplified DNA Junctions for High Grade Glioma Monitoring." The award period runs from August 1, 2025 to July 31, 2026. The project aims to develop and validate new diagnostic tools and technologies to improve early detection, monitoring, and management of...
- This federal Project Grant award of $1,782,155 from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) supports research by the Mayo Clinic to identify novel drug targets for lethal prostate cancer using liquid biopsy. The research aims to transform healthcare for military service members, veterans, and the broader public by advancing innovative medical solutions to critical health challenges. The award, with a performance period from April 1,...
- This $1,171,872 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop AI-assisted quantitative photon-counting-detector CT imaging capabilities for cytogenetic risk prediction and treatment response assessment in multiple myeloma. The key products and services to be delivered include: Development and validation of a deep...
- This federal Project Grant award of $412,429.00, provided by the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), supports research at the Mayo Clinic to investigate novel approaches for treating high-grade serous ovarian cancer (HGSOC). The research aims to evaluate how the nuclear translocation of cathepsin L (NCTSL) can sensitize CCNE1-driven HGSOC tumors to combination therapies involving DNA-damaging agents and PARP inhibitors. Key objectives include...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $390,916 Project Grant on Jan 15, 2025 to The Johns Hopkins University under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant funds research to optimize polymeric Chemical Exchange Saturation Transfer (CEST) Magnetic Resonance Imaging (MRI) agents for improved sensitivity and specificity in detecting prostate cancer. The key objectives are...
- The federal Project Grant award of $161,400.00 from the Defense Health Agency's Military Medical Research and Development program (CFDA 12.420) will support Mayo Clinic's research project titled "AN ATLAS OF THE TUMOR IMMUNE CIRCULOME." This award, with a performance period from June 1, 2024 to May 31, 2025, aims to advance medical knowledge and improve patient care through innovative biomedical research. The Military Medical Research and Development program funds a wide range of...
- This $997,410 Project Grant award from the National Cancer Institute under the Cancer Detection and Diagnosis Research program (CFDA 93.394) aims to develop non-invasive MRI-based techniques to detect and differentiate between the invasive neuronal (NEU) and glycolytic/plurimetabolic (GPM) subtypes of high-grade glioma brain tumors. The project leverages recent discoveries about these tumor subtypes' distinct microstructural, metabolic, and synapse profiles to enable more comprehensive tumor...
- The Defense Health Agency awarded a $152,192 Project Grant to Mayo Clinic in Rochester, MN under the Military Medical Research and Development program (CFDA 12.420) to develop a novel approach for the noninvasive molecular classification of kidney cancer using tumor-derived extracellular vesicles. The grant, with a performance period from November 1, 2025 to October 31, 2026, supports advanced biomedical research aimed at transforming healthcare for military service members, veterans, and the...
- The University of Pennsylvania received a $554,188 Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) to develop novel silver telluride nanoparticle contrast agents for use in dual-energy mammography screening of breast cancer, particularly in women with dense breasts. The 5-year project aims to advance these nanoparticle contrast agents towards clinical translation by adapting their synthesis using microfluidic chips to improve...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (CFDA 93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health) provides $443,850 to the Mayo Clinic to develop "G-quadruplex-based supramolecular assemblies as activatable contrast agents for in vitro and in vivo fluorescence imaging of estrogen receptor." The goal is to create a new class of activatable contrast agents to improve intraoperative tumor margin assessment during breast cancer lumpectomy procedures. The project will run from August 2025 to July 2027. Mayo Clinic, a renowned academic medical center, is the prime awardee on this grant. The funding supports their research into leveraging supramolecular assemblies and estrogen receptor-targeting to develop novel fluorescence-guided imaging tools for more accurate identification of tumor margins during surgery.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $443.9k | 8/13/25 |