Project Grant R21EB037152
- Federal Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded Boston University a $1.29 million Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) on August 1, 2025, with completion targeted for April 30, 2029. This award supports the development and evaluation of a self-amplifying RNA-based synthetic nanobody platform designed to transform antibody-based therapeutics and...
- Federal Project Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded the Trustees of Boston University a Project Grant of $613,124 under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) for the period August 15, 2025, through July 31, 2028. The project delivers the development and demonstration of Quantitative Phase Imaging Meta-Sensors (PIMSs)—advanced optical imaging sensors that...
- Federal Project Grant Award Summary The National Cancer Institute awarded $1.22M to the University of Massachusetts Boston under its Cancer Biology Research program (CFDA 93.396) effective August 1, 2025, through July 31, 2028. This project grant supports fundamental research to advance understanding of extracellular vesicles (EVs)—cell-derived, membrane-bound structures that carry biomolecules and serve as circulating biomarkers for disease diagnosis and therapeutic delivery. The research...
- Federal Grant Award Summary Northeastern University received a $219,818 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), with performance in Boston, Massachusetts from April 27, 2026 through January 31, 2029. The project focuses on developing a fully integrated electro-optic sensor system designed to enable real-time magnetic...
- Federal Project Grant Award Summary Boston College received a $641,700 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded August 1, 2026, with a completion date of March 31, 2031. The award supports the development of advanced chemical-proteomic tools and methodologies to investigate cysteine modifications across subcellular compartments. The research delivers investigator-initiated...
- Federal Project Grant Award Summary Boston University received a $1.93M project grant awarded September 15, 2025, by the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859) to develop advanced superresolution (SR) fluorescence microscopy technology using speckle illumination. The project, extending through August 31, 2029, aims to create robust, high-throughput SR imaging platforms that overcome current limitations in...
- Federal Grant Award Summary Brigham and Women's Hospital Inc. received a $749,901 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) for the period of May 1, 2026 through April 30, 2030. The award supports the development of an Interventional Drug Response Assay (IDRA) device designed to enable Phase-0 microdosing—a novel approach to drug...
- Federal Project Grant Award Summary Boston University received a $569,926 Project Grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), awarded August 1, 2025, with completion targeted for April 30, 2029. The grant funds development of a handheld spatial frequency domain imaging (SFDI) device using spiral illumination technology for non-invasive...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $230,762 to Trustees of Boston University, effective July 1, 2025 through February 29, 2028, under the Cancer Research Manpower program (CFDA 93.398). This award supports the development and investigation of disulfated polyamidosaccharide nanoparticles as a targeted chemotherapeutic delivery system for breast and lung cancers. The research addresses a critical clinical need by developing...
- Federal Grant Award Summary Boston University received a $449,625 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 5, 2026 through December 31, 2030. The award supports fundamental research to advance the development of virus-like particles (VLPs) as delivery vehicles for intracellular protein therapeutics. The research initiative leverages the institution's expertise in...
Boston University received a $641.3K Project Grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) for the period May 1, 2026 through April 30, 2029. The award supports development of next-generation chemoproteomic probes for targeted profiling of oncogenic kinase activity in circulating tumor cells (CTCs). The project advances cell-deliverable affinity-based peptide probes (CAFBPs)—specialized peptide molecules with tripartite structures designed for selective kinase phosphorylation recognition, bioconjugation functionality, and cellular uptake—to overcome current technical limitations in isolating and characterizing rare, heterogeneous CTCs from patient blood samples. The research deliverables focus on engineering improved CAFBPs with selective tumor cell uptake capabilities and enhanced endosomal escape mechanisms to enable more efficient intracellular delivery and kinase activity profiling. By addressing the critical obstacle of endosomal release and reducing the requirement for sample pre-enrichment, the project aims to develop bioanalytical tools that support minimally invasive kinase activity monitoring for functional biomarker-based risk stratification and targeted therapy selection. These technological innovations are expected to advance clinical applications in oncology by enabling more reliable analysis of CTCs from limited clinical samples, thereby improving disease monitoring and treatment response assessment capabilities.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $641.3k | 4/27/26 |