The University of Cincinnati received a $170,678 federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (CFDA 93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health) to develop and test new continuous electrochemical sensors for real-time monitoring of large molecules like proteins and peptides. The goal is to create sensors with unprecedented sensitivity improvements of over 1000% compared to existing solutions, enabling continuous in-vivo monitoring of analytes such as insulin, heart failure markers, and inflammatory proteins. This innovative work aims to overcome a major technological barrier that has limited the application of aptamer-based biosensors for large molecular targets. If successful, the project would provide a proof-of-concept to enable future human clinical studies on continuous monitoring of these clinically important analytes.
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