This federal Project Grant award, titled "Engineering Oral Tumor Microcirculation: Blood and Lymphatic Capillary Network-Enabled Human Oral Tumor Microenvironment Chips for Preclinical Research", is funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The $421,625 award, effective from July 1, 2025 to June 30, 2027, will support the development of advanced tumor microenvironment chips (TME-chips) that incorporate perfusable blood and lymphatic capillary networks. These innovative systems aim to recreate the tumor microenvironment of oral squamous cell carcinoma (OSCC) with unprecedented accuracy, integrating 3D tumor spheroids to explore angiogenesis, lymphangiogenesis, and microcirculatory dynamics. The project, led by the Texas A&M Engineering Experiment Station (Tees), seeks to advance understanding of OSCC progression and resistance to therapies, ultimately providing a platform for preclinical drug testing, biomarker discovery, and the design of more effective therapeutic strategies.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $421.6k | 6/25/25 |