Project Grant R21DC023019
- This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $767,494 to the University of Miami to develop human inner ear organoid platforms for studying genetic hearing loss and vestibular disorders. The key objectives are to: 1) establish and optimize human induced pluripotent stem cell-derived 3D inner ear organoid systems from patients with...
- This federal Project Grant award for $486,750.00 was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders (CFDA 93.173) program. The grant supports research to explore the morphological changes and cell polarity mechanisms in supporting cells of the inner ear, which play a critical role in auditory function. The primary awardee, the Jackson Laboratory, a nonprofit biomedical research...
- This federal Project Grant award of $781,703, awarded by the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA 93.173 "Research Related to Deafness and Communication Disorders", supports research to better understand sensory development in human cochlear organoids. The goals are to define the developmental trajectories of key sensory cell types, test methods to increase the number of hair cells, and accelerate the maturation of hair cells and sensory...
- This Project Grant award of $637,500.00 was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173). The goal of the project is to understand the forward transduction that drives inner and outer hair cell stereocilia, as well as the reverse transduction that amplifies motion in the human cochlea, using a novel finite element modeling technique. The research will focus...
- This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders federal grant program (CFDA 93.173), will support research to visualize the fluid compartments of the human inner ear using optical coherence tomography (OCT) imaging. The $1,403,696 award aims to characterize the normal endolymph-to-perilymph ratio in control subjects and compare it to subjects with Meniere's disease and...
- The federal Project Grant award of $111,321.00 from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), supports research conducted by President and Fellows of Harvard College (Harvard Medical School) to develop novel inner ear organoid models for studying hair cell development and Usher syndrome type 1F, a form of deaf-blindness. The research aims to overcome challenges in...
- This $647,518 Project Grant award, provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders (CFDA 93.173) program, supports research investigating the impact of cochlear synaptopathy on brainstem mechanisms of monaural temporal processing and binaural hearing. The study aims to understand the neural mechanisms and loci in the auditory system that produce listening difficulties, which can emerge...
- This federal Project Grant award of $257,256.00 was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders (CFDA 93.173) program. The grant will fund research aimed at investigating the molecular heterogeneity and regulation of vestibular ganglion neurons (VGNs) and their synaptic connections to vestibular hair cells in adult mice. The project seeks to characterize distinct VGN subtypes using...
- This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the "Research Related to Deafness and Communication Disorders" (CFDA 93.173) program, provides $711,342 to the Mayo Clinic to develop advanced imaging techniques for diagnosing inner ear disorders. Specifically, the grant will fund the use of photon counting detector computed tomography (PCD-CT) and artificial intelligence algorithms to produce high-resolution,...
- This federal Project Grant award of $662,162 was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders (CFDA 93.173) program. The award supports research by Oregon Health & Science University to investigate binaural spectral and temporal integration in individuals with hearing loss and hearing devices. The research aims to better understand abnormal binaural fusion and its association with...
This federal Project Grant award of $445,956, provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), is focused on establishing a molecular and physiologic biorepository of the human inner ear. The key objectives are to identify the normal physiology and molecular architecture of the human inner ear, and to determine whether findings from animal models also apply to humans, with the ultimate goal of identifying potential therapeutic targets for hearing loss and vestibular disorders. The award recipient, Vanderbilt University Medical Center, will collect inner ear tissues, including the cochlea and vestibular apparatus, as well as non-invasive physiologic data such as otoacoustic emissions. This research aims to address the significant gap in access to living human inner ear samples, which are critical for understanding this unique organ and developing improved treatment options for patients.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $446.0k | 8/7/25 |