This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $387,500.00 to The Johns Hopkins University from January 1, 2025 to November 30, 2029 to elucidate the gene regulatory networks that control hair cell regeneration in zebrafish. The research aims to identify key transcription factors, such as SOX and SIX, that regulate the transition of support cells to a progenitor state capable of...
This $1,145,674 federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), part of the National Institutes of Health (NIH), will fund research at Case Western Reserve University to investigate the role of TMC proteins in hair cell mechanotransduction in zebrafish. Specifically, the project aims to determine if TMCs contribute differently to zebrafish hearing, the role of TMCs in hair cell mechanotransduction and lateral line-mediated...
This federal Project Grant award of $781,703, awarded by the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA 93.173 "Research Related to Deafness and Communication Disorders", supports research to better understand sensory development in human cochlear organoids. The goals are to define the developmental trajectories of key sensory cell types, test methods to increase the number of hair cells, and accelerate the maturation of hair cells and sensory...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $767,494 to the University of Miami to develop human inner ear organoid platforms for studying genetic hearing loss and vestibular disorders. The key objectives are to: 1) establish and optimize human induced pluripotent stem cell-derived 3D inner ear organoid systems from patients with...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will provide $434,411 to Brandeis University to conduct research on the mechanisms of chemosensory neuron cilia regeneration. The goal is to identify the sensors, transducers, and effectors that drive the regrowth and restoration of function in sensory neuron cilia, which play a critical role in...
This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $251,856 to New York University from September 1, 2024 to August 31, 2026. The funding supports research investigating the neuroplastic processes underlying early adaptation to cochlear implants, which restore hearing and speech perception in individuals with severe or profound...
This Project Grant award of $257,256 from the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA Program 93.173 - Research Related to Deafness and Communication Disorders will support research to investigate the heterogeneity and molecular regulation of vestibular ganglion neuron (VGN) afferent terminal morphology. The project aims to: 1) Classify VGNs by their transcriptional profiles and correlate this to known anatomic VGN subtypes, and 2) Identify potential...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $147,486 to Emory University to study the neural mechanisms underlying recovery of sound localization after unilateral hearing loss in mice. The research aims to determine how changes in neural activity in the auditory cortex and inferior colliculus drive behavioral recovery of...
This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) will support research on the genetic causes of adult-onset hearing loss. The $676,533 award to the University of Pennsylvania aims to elucidate the role of the ZNF175/ZFP719 gene in pathogenic mechanisms leading to hearing loss, including investigating its effects on auditory synapses, ion...
The National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), awarded a $589,393 Project Grant to Northwestern University to support research on the development of cochlear innervation. The goal is to elucidate how the neural circuit in the mammalian cochlea assembles during development, by altering the identity of certain cell types involved. Through this project, the researchers will...