Project Grant R21CA309407
- Federal Grant Award Summary Georgetown University received a $401,115 Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) effective May 7, 2026, with completion by April 30, 2028. The project focuses on developing targeted-nanoparticle strategies to improve therapeutic outcomes for pancreatic ductal adenocarcinoma (PDAC), a cancer with exceptionally poor prognosis (5-year survival rate of approximately 13%). The...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Georgetown University a $656,469 Project Grant effective June 1, 2026, through May 31, 2031, under the Cancer Treatment Research program (CFDA 93.395). This award supports fundamental research investigating the regulation of de novo nucleotide synthesis and glioblastoma (GBM) response to radiochemotherapy. The research examines how the ZDHHC3 protein governs nucleotide synthesis by palmitoylating and enhancing...
- Federal Grant Award Summary Georgetown University received a $111,090 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), awarded January 21, 2026, with completion targeted for July 20, 2027. The award supports biomedical research training and scientific investigation into the role of Abelson tyrosine kinase 1 (c-ABL) in Wnt-dependent tumors, addressing a significant gap in cancer therapeutics where no FDA-approved treatments currently...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded $140,400 to Sloan-Kettering Institute for Cancer Research under the Cancer Research Manpower program (CFDA 93.398) to develop artificial intelligence (AI)-based methods that integrate genomic and histopathologic data to advance precision cancer medicine. This Project Grant, awarded July 17, 2026, and scheduled for completion by June 30, 2028, funds research focused on creating multimodal, interpretable AI models that combine...
- Federal Grant Award Summary Wake Forest University Health Sciences received a $402,728 Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded July 16, 2025, with completion targeted for June 30, 2027. The award supports development of interpretable deep learning models for multi-modality imaging-based gastric cancer prognosis. The project addresses the critical clinical need to improve prognostic accuracy and...
- Federal Grant Award Summary The National Cancer Institute awarded Columbia University a Project Grant of $702,132 under the Cancer Treatment Research program (CFDA 93.395) to conduct multiplex single-cell chemical genomics research focused on identifying small molecule modulators of glioblastoma immunogenicity. The project, which commenced June 11, 2026 and concludes May 31, 2029, will deliver high-throughput chemical transcriptomic profiling screening against 3,792 small molecules to...
- Federal Grant Award Summary The National Cancer Institute awarded a $371,161 Project Grant to the University of Colorado-Denver under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) on September 1, 2025, for a two-year performance period concluding August 31, 2027. The award funds the development of artificial intelligence (AI) algorithms designed to improve cervical cancer screening in low-resource settings. Specifically, the project will create advanced AI risk stratification...
- Federal Grant Award Summary New York University School of Medicine received a $681,215 Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) beginning September 1, 2025 and concluding August 31, 2030. The project aims to develop artificial intelligence (AI)-enabled magnetic resonance (MR) imaging technology to support point-of-care prostate cancer detection at the population level. The research challenges conventional...
- Federal Grant Award Summary Georgetown University received a $312,000 Project Grant from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective August 11, 2025, with a completion date of July 31, 2027. Principal Investigator Evan Lacy Pannkuk will develop a multiomic biodosimetry panel combining metabolomic and gene expression analysis to rapidly assess ionizing radiation (IR) exposure in large populations following...
- Project Grant Summary Georgetown University received a $663,383 Project Grant award from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393) on August 1, 2025, to support proactive outreach and streamlined genetic testing initiatives for prostate cancer survivors. The project, extending through July 31, 2030, addresses the critical gap between expanded germline genetic testing guidelines and low testing rates among the nation's over three million...
Georgetown University received a $412,167 Project Grant award from the National Cancer Institute under the Cancer Detection and Diagnosis Research program (CFDA 93.394), effective July 8, 2026, with completion scheduled for June 30, 2028. The project develops artificial intelligence-driven tools to automate the curation and analysis of immune-related adverse events (IRAEs) in cancer immunotherapy patients. The deliverables include a natural language processing (NLP) pipeline leveraging large language models to extract IRAE evidence, type, and grade from de-identified clinical notes, and a predictive machine learning model to identify patients at risk for adverse events early in immunotherapy treatment. These tools integrate structured clinical data including demographics with unstructured clinical narratives to support precision immunotherapy advancement. The project leverages Georgetown Lombardi Comprehensive Cancer Center's immune-oncology registry encompassing over 2,500 immunotherapy-treated patients across ten MedStar hospitals, supplemented with harmonized data from Hackensack Meridian Health's John Theurer Cancer Center containing 1,300 patients. The resulting annotated corpus, predictive models, and curation tools will be disseminated to the cancer research community to address the unmet need for comprehensive IRAE data registry support and to improve treatment management by reducing interruptions or discontinuation of immunotherapy caused by adverse events.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $412.2k | 7/9/26 |