Project Grant R21CA309323
- Federal Grant Award Summary The National Cancer Institute awarded a $731,503 Project Grant to Sloan-Kettering Institute for Cancer Research, effective June 1, 2026 through May 31, 2031, under the Cancer Cause and Prevention Research program (CFDA 93.393). The award funds a randomized controlled trial (RCT) evaluating Brief Behavioral Activation for Older Adult Cancer Survivors (BBA-OACS), a telehealth-based psychotherapy intervention designed to address clinically significant depression among...
- Federal Grant Award Summary The National Cancer Institute awarded Sloan-Kettering Institute for Cancer Research $1,467,021 under the Cancer Treatment Research program (CFDA 93.395) for a five-year project running from April 1, 2026 through March 31, 2031. This project focuses on identifying and targeting tumor regenerative cells (TRCs) that drive treatment resistance and metastatic recurrence in locally advanced rectal cancer (LARC) patients undergoing total neoadjuvant therapy (TNT). Through...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Sloan-Kettering Institute for Cancer Research a $747,660 Project Grant under the Cancer Cause and Prevention Research program (CFDA 93.393) on June 2, 2026, to develop and validate the RADIANT (Reducing Readmissions Through Innovative Applications of Telemedicine) trial. This five-year initiative, concluding May 31, 2031, combines remote patient monitoring (RPM) with integrative medicine (IM) interventions delivered via...
- Federal Project Grant Award Summary The National Cancer Institute awarded $292,028 to Sloan-Kettering Institute for Cancer Research under the Cancer Research Manpower program (CFDA 93.398) beginning August 1, 2025, and concluding July 31, 2030. This five-year Project Grant supports research investigating genome instability associated with focal oncogene amplification (OA) and the development of therapeutic strategies to address treatment-resistant cancers. The research deliverables include...
- Federal Project Grant Award Summary The National Cancer Institute awarded a Project Grant of $418,176.00 to Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) for the period September 1, 2025, through August 31, 2028. This three-year award supports the advanced development and validation of programmable nucleic acid cytometry, a technology designed to isolate and profile rare cell populations from tumors and tissues. Building on the...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Sloan-Kettering Institute for Cancer Research a $3.2 million Project Grant under the Cancer Cause and Prevention Research program (CFDA 93.393) beginning August 1, 2025, and concluding July 31, 2029. This research initiative investigates the mechanisms of extrachromosomal DNA (ecDNA) segregation and repair in cancer cells, with emphasis on understanding how ecDNA's circular topology contributes to tumor progression...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $730,398 to Sloan-Kettering Institute for Cancer Research through the Cancer Treatment Research program (CFDA 93.395) on September 1, 2025, for a five-year project period concluding August 31, 2030. This Project Grant supports research and development activities designed to advance novel treatment approaches for rectal cancer, with emphasis on organ preservation strategies that minimize patient morbidity. The...
- Federal Grant Award Summary The National Cancer Institute awarded a $444,590 Project Grant to Sloan-Kettering Institute for Cancer Research under the Cancer Treatment Research program (CFDA 93.395) on June 2, 2026, with completion targeted for May 31, 2028. The project focuses on evaluating genetic and epigenetic determinants of treatment response in patients with accelerated and blast phase myeloproliferative neoplasms (MPNs), rare blood cancers with poor prognosis and limited effective...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Sloan-Kettering Institute For Cancer Research a $452,540 Project Grant under the Cancer Treatment Research program (CFDA 93.395) effective July 1, 2025, through June 30, 2027. This award supports research to develop and validate electronic nose (e-nose) technology utilizing volatile organic compounds (VOCs) in patient exhalates to predict and assess pathologic response to neoadjuvant therapy in patients with...
- Federal Project Grant Summary The Sloan-Kettering Institute for Cancer Research received a $246,362 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), awarded June 12, 2026, with a completion date of May 31, 2031. This grant supports research investigating the evolutionary landscape of BRCA-associated breast cancer and its impact on endocrine therapy resistance. The project addresses a critical gap in cancer treatment, as...
Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $457,252 Project Grant to Sloan-Kettering Institute for Cancer Research under the Cancer Cause and Prevention Research program (CFDA 93.393) on June 10, 2026, with a completion date of May 31, 2028. The award supports the development and implementation of RECONJOINT, a web-based decision support tool designed to improve shared decision-making for breast reconstruction surgery. The tool utilizes adaptive choice-based conjoint (ACBC) analysis to systematically elicit and integrate individual patient preferences into treatment planning, addressing a critical gap in current surgical decision-making processes where 40% of patients report dissatisfaction and decisional regret. Under Aim 1, the awardee will design a comprehensive implementation toolkit informed by focus groups and developed collaboratively with patients, providers, and patient advocates. The toolkit will include a treatment preferences report, educational video content on the tool and existing evidence, and recommendations for clinical integration of patient preferences into shared decision-making. Under Aim 2, the project will conduct a pilot cluster-randomized evaluation to assess the feasibility, acceptability, and preliminary efficacy of the RECONJOINT intervention in a clinical setting. These deliverables directly address the program's objectives to identify risk reduction strategies and develop preventive interventions while advancing patient-centered cancer care outcomes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $457.3k | 6/11/26 |