Project Grant R21CA307890
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The University of Kentucky Research Foundation a Project Grant of $124,546 under the Cancer Research Manpower program (CFDA 93.398) to support cancer research training and investigation. The award, obligated on July 14, 2025, funds a two-year project (completion date June 30, 2027) titled "Enhancing TIL Efficacy in NSCLC Through Epigenetic Reprogramming and Computational Modeling." The project...
- Federal Grant Award Summary The National Cancer Institute, under its Cancer Detection and Diagnosis Research Program (CFDA 93.394), awarded the University of Vermont & State Agricultural College a $595,012 Project Grant on April 13, 2026, with a completion date of March 31, 2031. This award supports the development and refinement of an image-enabled computational dosing model for intratumoral cisplatin delivery in non-small cell lung cancer (NSCLC) treatment. The research addresses...
- Federal Grant Award Summary The National Cancer Institute awarded the University of Dayton a $451,131 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) on July 9, 2025, with a completion date of May 31, 2028. Led by Principal Investigators Shawn Swavey (Department of Chemistry) and Kristen Krupa (Department of Chemical and Materials Engineering), this project will develop endoplasmic reticulum (ER)-targeting boron dipyrrin (BODIPY) fluorescent imaging agents...
- Federal Grant Award Summary The National Cancer Institute awarded a $388,546 Project Grant under the Cancer Biology Research program (CFDA 93.396) to the University of Texas Health Science Center at Houston, effective June 1, 2026 through May 31, 2031. This five-year research project investigates the Golgi secretory pathway in chromosome 3q-amplified non-small cell lung cancer (NSCLC), with the goal of developing targeted therapeutic approaches for NSCLC cases lacking actionable mutations in...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Johns Hopkins University a $144,193 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) effective September 4, 2025 through August 31, 2030. This award provides protected salary support for Dr. Preethi Korangath to serve as a Laboratory Research Specialist in Dr. Robert Ivkov's laboratory, where she will facilitate the completion of Research Project Grants (R01) by leveraging her expertise...
- Federal Grant Award Summary The National Cancer Institute awarded a $635,340 Project Grant to The Leland Stanford Junior University on May 4, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393). The research project, titled "Functional Genomic Dissection of Lung Cancer In Vivo," will operate through April 30, 2031, and aims to identify and characterize tumor suppressor genes and their functional roles in lung cancer development. The grant supports the development...
- Federal Grant Award Summary The National Cancer Institute awarded Massachusetts General Hospital (the awardee) a Project Grant of $682,140 on June 4, 2026, under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) to develop and validate the SPIDER (Synthetic Potentiated Immunogenic Depot Engaged by Radiation) platform for treating locally advanced non-small cell lung cancer (NSCLC). The deliverables include the development of radiation-responsive nanoparticles capable of...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $716,521 to Sloan-Kettering Institute for Cancer Research on August 25, 2025, under the Cancer Treatment Research program (CFDA 93.395). The award supports the development and clinical evaluation of DLL3-targeted IL18-secreting chimeric antigen receptor (CAR) T cells for treating small cell lung cancer (SCLC). The research initiative addresses a critical clinical need, as SCLC currently demonstrates...
- Federal Grant Award Summary The National Cancer Institute awarded a $164,484 Project Grant to The University of Kentucky Research Foundation on August 11, 2025, under the Cancer Cause and Prevention Research program (CFDA 93.393). This award supports a research initiative focused on developing and evaluating health communications targeting adults who smoke nondaily (ASN)—a population representing approximately one-third of current adult cigarette smokers in the United States yet demonstrating...
- Federal Grant Award Summary The National Cancer Institute awarded The Institute For Cancer Research a $483,395 Project Grant under the Cancer Treatment Research program (CFDA 93.395) beginning September 1, 2025, and concluding August 31, 2027. This research initiative focuses on investigating P300 and CBP (Cyclic AMP-Response Element Binding Protein) as novel therapeutic targets in renal cell carcinoma (RCC), specifically clear cell RCC (ccRCC). The project will examine the therapeutic potential...
The National Cancer Institute awarded $395,973 to The University of Kentucky Research Foundation under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) on June 9, 2026, for a project period extending through May 31, 2028. The project investigates single-cell resolution imaging of drug resistance in non-small cell lung cancer (NSCLC) patients, with particular focus on how toxic metal exposure in the tumor microenvironment (TME) contributes to therapeutic resistance and cancer progression in Kentucky's Appalachian population, which experiences the nation's highest lung cancer incidence and mortality rates. The research deliverables include development and application of advanced analytical methodologies to characterize metabolic heterogeneities within patient-derived organotypic tissue cultures (PD-OTC) that retain native tumor architecture and microenvironmental functions. The project employs stable isotope-resolved metabolomics, reverse phase protein array analyses, digital spatial profiling of transcripts and proteins, and laser ablation coupled with inductively coupled plasma mass spectrometry to achieve single-cell resolution mapping of oncometabolic proteins and toxic metals, particularly chromium and lead, in NSCLC tissues. These research activities are designed to generate critical insights into how toxic metal co-morbidities interact with tumor metabolism to promote drug resistance, ultimately improving therapeutic strategies and patient outcomes for lung cancer patients.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $396.0k | 6/12/26 |