Project Grant R21CA299788
- Federal Grant Award Summary The University of Pittsburgh received a $408,829 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) effective June 1, 2025, through May 31, 2027. This award supports the development of positive allosteric modulators (PAMs) targeting XCR1, a chemokine receptor expressed on conventional dendritic cells subtype 1 (CDC1s). The research will utilize DNA-encoded library (DEL) technology and cryo-electron...
- Federal Grant Award Summary The National Cancer Institute awarded the University of Pittsburgh a $151,920 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective September 1, 2025, through August 31, 2027. This award supports fundamental research to develop and validate Nuclear Magnetic Resonance (NMR) strategies for investigating allosteric inhibitor binding effects on Src-family kinases implicated in acute myeloid leukemia (AML). The research aims to characterize...
- Federal Grant Award Summary The University of Pittsburgh received a $169,982 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) awarded August 8, 2025, through July 31, 2030. The Program in Cancer Training and Education (PICTE) initiative provides comprehensive research training and professional development services for undergraduate students pursuing careers in cancer research. The award funds a 10-week intensive summer research program...
- Federal Project Grant Award Summary The University of Pittsburgh received a $261,662 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), awarded December 1, 2025, with completion targeted for April 16, 2029. This award supports an integrated in silico and in vivo genetic screening research initiative designed to identify subtype-specific hepatocellular carcinoma (HCC) genetic dependencies. The project addresses a significant clinical...
- Federal Grant Award Summary The National Cancer Institute awarded the University of Pittsburgh a $141,566 Project Grant on March 24, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support biomedical research training and career development in cancer research. The grant funds research focused on understanding the conformational landscape and regulation of small GTPases (SMGs), specifically examining how oncogenic RhoA proteins function in cancer cell environments. The project...
- Federal Project Grant Award Summary The University of Pittsburgh received a $408,829 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective September 1, 2025 through August 31, 2027. This award supports the development of an integrative framework for surface protein imputation in spatial biology applications. The project delivers machine learning (ML) methodologies and computational tools designed to predict surface protein abundance...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of Pittsburgh a Project Grant totaling $649,620 (awarded May 1, 2026; completion April 30, 2031) under the Cancer Cause and Prevention Research program (CFDA 93.393) to conduct research on Medicare Advantage insurance impacts on cancer care access and outcomes. The research will analyze coverage patterns and care quality for beneficiaries with the four most prevalent cancers—breast, colorectal, lung,...
- Federal Grant Award Summary The University of Pittsburgh has received a $121,857 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) effective August 1, 2025, through July 31, 2027. This award supports a K99/R00 Pathway to Independence research project investigating how anti-cancer drugs modulate T cell activity within the tumor microenvironment to overcome immune checkpoint blockade (ICB) resistance. The research delivers three integrated...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Pittsburgh a Project Grant of $658,492 under the Cancer Treatment Research program (CFDA 93.395) to develop and evaluate a novel targeted combinatorial therapy for advanced castration-resistant prostate cancer (ACRPC). The research, spanning from March 18, 2026 through February 28, 2031, focuses on optimizing the combination of CHK1 inhibitor SRA737 and WEE1 inhibitor AZD1775 to exploit the G2/M...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Pittsburgh a $657,776 Project Grant under the Cancer Treatment Research program (CFDA 93.395) beginning August 1, 2025, and extending through May 31, 2030. This award supports the development of highly tumor-selective pan RAS inactivators to address oncogenic RAS-driven cancers, which account for approximately 46% of all human malignancies. The project addresses a significant clinical challenge: while...
The University of Pittsburgh received a $396,799 Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) to develop biomarkers and computational models for predicting adenoma recurrence in patients with advanced adenomas. The award, effective April 1, 2026 through March 31, 2028, supports research addressing a significant clinical challenge: approximately 15% of colonoscopy patients are found to have advanced adenomas (AA), which carry a 3-fold higher risk of developing into colorectal cancer compared to those with normal findings. The research will employ two novel approaches to evaluate colorectal lesions: evaluation of aberrant alterations in chromatin structure at nanoscale sensitivity and spatial analysis of lesion characteristics. These research deliverables aim to establish robust molecular biomarkers and reliable predictive tools that can personalize surveillance examination timing, improve patient outcomes, and optimize resource allocation while potentially reducing colorectal cancer incidence. The project directly supports the NCI's Cancer Detection and Diagnosis Research Program objectives by developing accurate diagnostic techniques and methods for predicting disease course in cancer patients. By moving beyond current endoscopic assessment and pathologic review criteria—which are subject to interobserver variability—the research will establish molecularly-defined risk stratification for advanced adenomas. The resulting biomarkers and computational models are intended to inform prevention treatment strategies and improve the clinical management of precancerous colorectal lesions across the estimated 15 million colonoscopy examinations performed annually in the United States.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $396.8k | 3/26/26 |