Project Grant R21CA297400
Award Date
12/1/24
Completion Date
11/30/26
Dollars Obligated
$425K
Federal Agency
National Cancer Institute
Federal Grant Program
93.396
Assistance Type
Project Grant
Place of Performance
Chicago, IL 60612, USA
Similar Awards
This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $449,726 to the University of Illinois to develop new tools that will enable rapid analysis of changes in protein interactions within living cells. The goal is to significantly improve the sensitivity and temporal resolution of existing approaches for mapping dynamic changes in protein interactomes, which is critical for understanding signaling processes driving tumor formation and...
The National Cancer Institute (NCI), under the federal Cancer Biology Research grant program (CFDA 93.396), has awarded a $632,300 Project Grant to Carnegie Mellon University (CMU) to develop an integrated ultra-high-throughput 3D volumetric super-resolution imaging system. This system will combine a multiscale fluorescence mesoscope with magnify expansion microscopy to enable rapid, large-area 3D imaging with exceptional subcellular detail. The goal is to study interactions between cancer and...
This $222,027 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research (CFDA 93.396) program supports the development of a novel computational imaging algorithm to characterize the mechanobiology of three-dimensional tumor microenvironments (TMEs). The University of Pittsburgh, the grant's recipient, aims to combine high-resolution digital pathology imaging and highly multiplexed immunofluorescence microscopy with physical optics-based principles to...
The National Cancer Institute (NCI) awarded a $417,586 Project Grant (CFDA 93.396 - Cancer Biology Research) to The Broad Institute, Inc. to develop a "Platform for Multi-Modal Single Nucleus Spatial Genomics for Molecular Tumor Analysis." This 3-year project, commencing on August 1, 2024, aims to extend the institute's "Slide-Tags" single-cell spatial genomics technology to enable comprehensive profiling of human tumor samples. The project will integrate molecular, cellular,...
This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) will provide $169,932 from September 2024 to July 2029 to The Trustees of Columbia University in the City of New York to advance proteomics technologies for cancer research. The award will enable the recipient's Proteomics and Macromolecular Crystallography Shared Resource to enhance its capabilities by developing innovative methodologies, including automated deep proteomic profiling for...
This Project Grant award of $186,250 from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) supports the development and characterization of membrane-sensitive fluorescent probes to measure the local nano-environment around membrane proteins in living cells. The award to the University of Virginia aims to overcome technology gaps in directly observing the "paralipidomes" - the specific lipid compositions that assemble around membrane proteins...
This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) will support the development of a novel approach to detect and report on the expression of multiple cytokine genes simultaneously in tissues. The $234,919 award to Yale University, to be completed by August 31, 2027, will combine CRISPR-mediated transcriptional activation with genetically-encoded fluorescent reporters to enable the dynamic, high-sensitivity and multiplexed monitoring of cytokine...
This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) totaling $227,906 will support the development of a novel technology for spatially resolved multi-omics sequencing of formalin-fixed paraffin-embedded (FFPE) tissue samples at the cellular level. The key products and services to be delivered under this award include: Developing spatial epigenome sequencing capabilities to measure gene expression and epigenetic characteristics directly in...
The National Institute of General Medical Sciences (NIGMS) awarded a $333,048 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. in Houston, TX. The goal of this 1-year project is to develop a versatile 2-photon microscopy platform, dubbed 2P-SPOTLIGHT, to isolate individual cells from 3D tissue samples and 3D cell cultures based on their spatial and temporal properties. This will enable researchers to conduct downstream multi-omics...
The National Cancer Institute (NCI) awarded a 5-year, $640,522 Project Grant (CFDA 93.396 - Cancer Biology Research) to The Leland Stanford Junior University to elucidate how microbial microproteins modulate macrophage function, a critical coordinator of tumor immune response. The central hypothesis is that specific gut microbes express microproteins that directly modulate macrophages, leading to immunomodulation of cancer. The project will: 1) Determine the molecular mechanisms by which two...