This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to Weill Medical College of Cornell University supports research to investigate the role of the p53 gene in determining the ability of radiation therapy to induce an anti-tumor immune response. The $237,724 award, granted on March 12, 2025, will fund studies using various p53-mutant and wild-type mouse and human cancer cell lines, as well as patient-derived tumor organoids, to evaluate how p53 status affects radiation-induced activation of the interferon-I signaling pathway and in situ immunization. The goal is to identify the p53 mutational status as a key determinant of radiation's pro-immunogenic effects, which could help guide the selection of patients most likely to benefit from combination radiation and immunotherapy treatments.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $237.7k | 3/12/25 |