The University of Texas Health Science Center at Houston (UTHealth) received a $406,217 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) to conduct research on the circadian regulation of astrocytic adenosine kinase in the irradiated and cancer brain. The award, effective from July 11, 2024 to June 30, 2026, aims to investigate how cranial radiotherapy for brain cancers disrupts the circadian clock and sleep-wake regulation in normal and cancerous brain tissue, with a focus on the role of the transcription factors BMAL1 and CLOCK in controlling astrocytic adenosine kinase expression. This research seeks to reveal key mechanisms underlying sleep and cognitive impairments experienced by brain cancer patients undergoing cranial radiotherapy.
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