This Project Grant award of $368,288 from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research (CFDA 93.393) program supports research to investigate molecular and genetic differences that may contribute to disparate lung cancer outcomes experienced by patients of African ancestry. The research project, led by Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, aims to: 1) determine how EGFR signaling differs based on patient genetic...
The National Cancer Institute awarded a $256,487 Project Grant under the Cancer Research Manpower (CFDA 93.398) program to the Sloan-Kettering Institute for Cancer Research in New York, NY. The grant supports a 5-year research project to develop multimodal predictive models combining real-world data from circulating tumor DNA (ctDNA) sequencing, radiomics, tumor genomics, and clinical notes to improve risk stratification and clinical management of non-small cell lung cancer (NSCLC). The research...
This $583,127 five-year Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research by the Sloan-Kettering Institute for Cancer Research to elucidate the mechanisms by which deficiency in the SMARCA4 gene promotes metastasis in lung adenocarcinoma. The key research objectives are to: 1) investigate how SMARCA4 deficiency regulates transcription and chromatin accessibility to drive metastasis, and 2) evaluate the therapeutic potential of...
This federal Project Grant award of $2,372,456.00 from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) supports a multi-institution research program led by the Sloan-Kettering Institute for Cancer Research. The program aims to leverage observational (real-world) data to advance precision oncology and address key challenges, including patient response heterogeneity, disparities in driver mutation frequencies across populations, and operational challenges in...
The National Cancer Institute (NCI) awarded a $455,111 Project Grant under CFDA 93.393 "Cancer Cause and Prevention Research" to the Sloan-Kettering Institute for Cancer Research in New York. The 2-year grant, awarded on September 5, 2023, will support research to "Leverage the Hidden Genome to Recover the Missing Heritability of Cancer." The project aims to 1) estimate additional heritability that can be explained by the "hidden genome" (regions of unknown...
This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports research to develop effective therapeutic strategies for non-small cell lung cancers with SMARCA4 gene deficiencies. The $557,418 grant, awarded to Columbia University's Health Sciences Division, aims to evaluate the impact of selectively degrading the SMARCA2 protein as a treatment approach for this aggressive lung cancer subtype. The research leverages genetically engineered mouse...
The Sloan-Kettering Institute for Cancer Research was awarded a $923,999 Project Grant from the Defense Health Agency's Military Medical Research and Development program (CFDA 12.420) to conduct research on understanding the effects of tobacco smoking on African American patients with lung cancer. The award will support a multi-year research initiative from July 1, 2024 to June 30, 2027. As a non-profit organization focused on cancer research and patient care, Sloan-Kettering Institute for...
This $3,787,956 federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to New York University School of Medicine will fund research to understand and target replication stress in small cell lung cancer (SCLC). The project aims to investigate how the SLFN11 gene and replication stress response pathways influence SCLC chemosensitivity, with the goal of developing novel strategies to overcome acquired chemoresistance. The research will leverage...
This $306,999 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) is focused on developing an integrated machine learning framework to accurately identify lung cancer subtypes. The key products and services to be delivered include: Establishing a gene signature-transfer machine learning model that leverages large-scale bulk and single-cell transcriptomics data, both within and beyond NIH Common Fund...
This $627,833 Project Grant award from the National Cancer Institute's Cancer Biology Research Program (CFDA 93.396) aims to develop an informatics platform that integrates molecular and pathological data from various lung cancer preclinical models and patient tumors. The key products and services to be delivered include: Harmonizing molecular profiling datasets from multiple lung cancer preclinical models and implementing statistical methods for cross-study validation and quality control....