This $430,684 Project Grant awarded by the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) supports research at Yale University to study the role of the TENT2 enzyme in regulating microRNA (miRNA) levels and tumor angiogenesis in non-small cell lung cancer (NSCLC). The project aims to determine how TENT2-mediated 3' adenylation of miR-1 leads to its degradation in tumor endothelial cells, and the impact of this mechanism on NSCLC tumor angiogenesis and progression. The research will provide fundamental insights into the molecular basis of NSCLC that could inform new diagnostic, preventive, or therapeutic approaches. The project period runs from July 2024 to June 2026.
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