The National Cancer Institute (NCI), through its Cancer Treatment Research program (CFDA 93.395), has awarded a $402,402 R21 project grant to the University of Louisville's Office of Research & Innovation. The goal of this 2-year grant, which began on September 19, 2023, is to develop and evaluate a novel tumor glycobiomarker-targeting agent called AVFC Lectibody as a potential immunotherapeutic and diagnostic agent against non-small cell lung cancer (NSCLC). The research aims to assess AVFC's efficacy for improving survival and modulating the tumor immune microenvironment in a preclinical NSCLC mouse model. It will also analyze the biodistribution and tumor-targeting capabilities of radiolabeled AVFC derivatives using microPET/CT imaging. The results are expected to facilitate further preclinical development of AVFC towards an eventual Phase I clinical trial for NSCLC treatment.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $402.4k | 9/19/23 |