The University of Connecticut Health Center (UCHC) received a $422,874 federal Project Grant award from the National Cancer Institute's Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop an in vitro bone metastasis model for prostate cancer research. The 2-year project aims to create a well-defined 3D bioprinted tumor microenvironment model that mimics the molecular, cellular, and metabolic interactions in the bone-tumor microenvironment of metastatic prostate cancer. This model is intended to serve as a preclinical screening platform to accelerate the development of novel therapeutic agents targeting prostate cancer bone metastases. As part of the project, Washington State University will prepare PSMA-targeted fluorophore/drug-conjugates and assess their stability, release, and binding potency to support the overall research goals.
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