Project Grant R21AT013465
- The federal Project Grant award titled "Biophysical Characterization of the Human Force-Gated Ion Channel PIEZO2" was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $126,048 award will support research to determine the fundamental biophysical properties of the human PIEZO2 ion channel and investigate how tissue-specific alternative...
- This Project Grant award of $636,822 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at Western University of Health Sciences to study the cooperative modulation of piezo ion channels. The research aims to use multi-scale molecular dynamics simulations, high-speed single molecule imaging, and high-resolution electrophysiology to investigate how mechanical forces and channel collisions influence the activity of piezo channels...
- This $440,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports a comprehensive research program to decipher the principles and mechanisms of cellular mechanosignaling. The Principal Investigator will leverage a multi-fluorescence biomembrane force probe platform, in combination with molecular/cellular engineering, super-resolution imaging, biophysical modeling, and molecular...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to elucidate the underlying molecular mechanisms of cellular mechanosensitivity. The $387,662 award to Duke University will enable the development of novel biosensors and techniques to investigate how mechanical forces and protein phosphorylation regulate the mechanical state and force transmission capabilities of key linker...
- This Project Grant award of $691,089.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) supports research to investigate the role of mechanosensing and mechanotransduction in joint homeostasis and osteoarthritis (OA) susceptibility. The research aims to determine how mutations in the PIEZO1 mechanosensitive cation channel affect PIEZO1 activity and influence OA development. The project will use biophysical analyses, cellular/molecular studies, and mouse...
- This $429,000 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of Schwann cell PIEZO1 in pain sensation. The key objectives are to: 1) develop and validate adeno-associated virus (AAV) vectors for selective inhibition of Schwann cell PIEZO1, and 2) determine the sensory effects of Schwann cell...
- This federal Project Grant award, valued at $427,625.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on the conformational dynamics and regulatory mechanisms of the KCNH family of ion channels. The research aims to examine the voltage sensor domain and S4 helix of KCNH channels to measure their structural changes during channel opening and closing. The project will...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $541,967 to the University of Chicago to investigate the mechanical behaviors of cells and their impact on physiological processes and diseases. The research aims to expand the understanding of adherent cell mechanics and mechanobiology, focusing on the force-sensitive remodeling of cell-cell adhesions and the role of LIM...
- The National Science Foundation (NSF) awarded a $253,890 Project Grant under the Biological Sciences program (CFDA 47.074) to Western University of Health Sciences to conduct research on sensory membrane proteins. The goal is to develop computational tools capable of realistic simulations of how these proteins respond to external stimuli like pressure, heat, and sound. The research project, titled "Collaborative Research: Ultra-Fast Simulations of Sensory Membrane Proteins with Validation...
- This $576,104 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports fundamental research on the molecular mechanisms underlying transmembrane conduction and signaling in integral membrane proteins. The research aims to define the structural transitions and energy coupling processes that drive and regulate cyclical processes in membrane proteins, with a focus on understanding voltage...
This Project Grant award, titled "DYNAMICS AND HETEROMERIZATION OF PIEZO CHANNEL SUBUNITS - SUMMARY THE RAPID DETECTION OF MECHANICAL STRESS - AND ADAPTATION TO IT - IS ESSENTIAL TO ALL ORGANISMS", was provided by the National Center for Complementary and Integrative Health (NCCIH) under the federal Research and Training in Complementary and Integrative Health program (CFDA 93.213). The $390,979 award aims to investigate how the Piezo1 and Piezo2 mechanosensitive ion channels in vertebrates interact to transduce diverse mechanical stimuli. The research will use bimolecular fluorescence complementation, co-immunoprecipitation, and fluorescence resonance energy transfer to test hypotheses around Piezo subunit heteromerization and conformational changes. The 2-year project will be conducted by Western University of Health Sciences in California, with an award period from Sep 1, 2025 to Aug 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $391.0k | 8/20/25 |