Project Grant R21AR086384
- The University of Pennsylvania was awarded a $174,420 Project Grant by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The grant, awarded on May 1, 2025, will support research led by Dr. Leo Wang to develop hydrogel-based therapies for treating alopecia areata, a common autoimmune skin disease that causes hair loss. The project will leverage the specialized...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to understand the plasticity of melanocyte stem cells (MCSCs) and mature melanocytes in adult hair follicles. The $1,917,396 award to New York University School of Medicine will support live-imaging techniques to delineate the fate decision process of MCSCs, from partial differentiation...
- This $224,100 federal Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to identify epigenetic factors that control the longevity of epidermal stem cells in adult skin. The project aims to elucidate the functional role of epigenetic regulators and their corresponding histone modifications in maintaining the longevity of hair...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) provides $249,000.00 to the University of Massachusetts Medical School to develop a therapeutic platform using small interfering RNA (siRNA) for gene silencing in the treatment of skin diseases. The project aims to evaluate the safety and efficacy of silencing the JAK1 immune mediator in...
- This Project Grant award, titled "Skin Microbes and Development of Allergic Disease," is funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $5,176,858 award will support research at the University of California, San Diego (UCSD) to investigate how colonization by specific strains of Streptococcus bacteria that can damage the skin barrier may increase the risk of developing allergic...
- This federal Project Grant award of $528,558.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The goal of the research project is to study the immune system mechanisms underlying treatment resistance and paradoxical inflammatory side effects in patients with atopic dermatitis who receive the antibody therapy dupilumab. The research will...
- This $300,000 Project Grant award was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) to the University of Rochester. The project aims to "Decipher the Endotypes and Signature of Non-Response in a Humanized Murine Model of PSA" for psoriatic arthritis, a chronic inflammatory disease. The research will (1) identify cellular and molecular signatures across psoriatic arthritis tissue domains, (2) define CD8+ T cell...
- This federal Project Grant award for $243,950.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports a series of research aims to develop prognostic models for predicting the long-term course of atopic dermatitis (persistent disease and comorbidities) in diverse global settings, including cohorts from Uganda, Ecuador, and the United Kingdom....
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is supporting research to discover and develop novel small molecule therapeutics for vitiligo. The $306,278 award to Aohbio Corporation, located in Athens, OH, aims to investigate the efficacy of the lead compound COB-187 in inhibiting interferon-gamma induced CXCL10 expression by human...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $2,070,827 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) to the Icahn School of Medicine at Mount Sinai. This grant aims to identify novel microbial factors that can enhance wound repair, a significant public health issue with over 100 million new acute skin wounds annually and substantial treatment costs exceeding $25 billion. The...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the role of gut microbiome and dietary gluten in the autoimmune condition of alopecia areata. The $384,519 award, with a project period from August 15, 2025 to July 31, 2027, will fund research focused on two key objectives: 1) examining how gluten-induced gut dysbiosis affects gut permeability and immune system activation, and 2) exploring how specific gut bacteria metabolize gluten to generate immunogenic peptides that contribute to alopecia areata progression. The research will utilize established mouse models and advanced microbiome analysis techniques to uncover the precise mechanisms by which dietary gluten and the gut microbiome influence this autoimmune hair loss disorder. The findings may inform the development of personalized dietary and microbiome-targeted interventions to improve the management of alopecia areata.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $384.5k | 7/28/25 |