The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $647,460 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Cornell University to support research on the mechanisms of mechanically-induced gene expression in skeletal muscle cells. The five-year project, running from September 1, 2024 to August 31, 2029, aims to define the nuclear mechanisms responsible for the ultra-rapid activation of mechanoresponsive genes in...
This federal Project Grant award of $621,703, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to understand the mechanisms of tendon repair and develop treatments for tendinopathy. The award, with a period of performance from Sep 1, 2024 to Aug 31, 2029, will fund Cornell University's investigation into how changes in glycosaminoglycans (GAGs)...
This federal Project Grant award of $219,605.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to identify the role of the mechanosensitive ion channel PIEZO1 in driving synovial fibrosis and inflammation in post-traumatic osteoarthritis (PTOA). The research will characterize the bi-directional regulation between PIEZO1 mechanotransduction and...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $196,460 Project Grant (CFDA 93.846) to the University of Pittsburgh to test a novel microphysiological system for studying neuro-immune interactions in osteoarthritis pain. The project aims to understand the influence of synovial-like tissue inflammatory molecules on innervating neurons, assess the role of chemokines and neuropeptides on pain and inflammation, and develop a platform for testing...
This federal Project Grant award, totaling $296,536.00, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The objective of the project is to establish a detailed biophysical and biochemical understanding of how mechanical loading enhances cartilage formation in chondrocytes, the cells that produce cartilage in joint tissues. Specifically, the research will...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $220,224 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to The Regents of the University of Colorado, operating as the University of Colorado, with a period of performance from July 4, 2024 to August 31, 2027. The funding will support the development of granular hydrogels for the controlled delivery of immunomodulatory and angiogenic extracellular vesicles to enhance...
This federal Project Grant award, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to elucidate the mechanistic link between altered gait biomechanics and the development of knee osteoarthritis. The $644,152 award will support research conducted by the University of North Carolina at Chapel Hill to: 1) determine the acute in vivo effects of sustained versus...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded Vanderbilt University a $393,412 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to develop engineered cells as agents for treating osteoarthritis. The project aims to leverage advanced cell design platforms to create synthetic receptor-controlled, joint-resident cells that can detect cartilage degeneration and then upregulate the expression of transgenes to promote...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $1,037,340 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to The Broad Institute, Inc. The grant will be used to transform the early-stage Musculoskeletal Knowledge Portal (MSKKP) into an established biomedical knowledgebase. This will involve integrating numerous genomic datasets related to bone, cartilage, tendon, synovial fluid, and muscle conditions, as well as...
This $483,070 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA 93.846 "Arthritis, Musculoskeletal and Skin Diseases Research" supports research into the dynamics of bone extracellular matrix (ECM) assembly and resorption. The study aims to investigate how osteogenic cellular dynamics, differentiation, and cell fate are integrated with collagen assembly and mineralization, as well as how osteoclast bone resorption...