Project Grant R21AI202368
- The National Institute of Allergy and Infectious Diseases awarded the University of Florida $230,250 on April 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop an artificial intelligence-driven computational framework for predicting Kaposi's sarcoma-associated herpesvirus (KSHV) protein interactions with human host proteins, with emphasis on identifying viral proteins that suppress cGAS-STING immune signaling. The project combines deep learning and...
- Federal Grant Award Summary The University of Florida's Division of Sponsored Research received a $402,150 Project Grant award dated July 23, 2025, from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research award, with a completion date of June 30, 2027, supports investigator-initiated biomedical research focused on understanding the viral mechanisms by which Kaposi's Sarcoma-Associated Herpesvirus...
- The National Institute of Allergy and Infectious Diseases awarded Florida State University $372,997 on April 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate cytosolic DNA sensing pathway regulation via non-canonical NF-kB signaling. The project examines how cytosolic DNA pattern recognition receptors control type I interferon activation, with focus on the cross-talk between cytosolic DNA sensing and the non-canonical NF-kB signaling pathway....
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded the University of Florida $454,738 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how cytosolic pattern recognition receptors sense membrane-replicating positive-strand RNA viruses despite viral replication sequestering viral RNA from host cell cytoplasmic sensors. The research addresses a fundamental paradox in...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded the University of Florida $111,342 on December 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research elucidating the antiviral mechanisms of OAS family innate immune sensors. The award funds investigation into how oligoadenylate synthetase (OAS) proteins recognize viral RNA and activate innate immune responses to restrict viral...
- The National Institute of Allergy and Infectious Diseases awarded the University of Florida $750,263 on June 4, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how bacteriophage predation influences diarrheal disease severity and antimicrobial resistance emergence. The research uses cholera as a model system to validate findings in a new patient cohort and tests underlying theory across high-priority enteric pathogens including Shigella species and...
- The National Institute of Allergy and Infectious Diseases awarded the University of Florida $230,250 on July 14, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct structural and biophysical characterization of adeno-associated virus (AAV) genome packaging and ejection mechanisms for enhanced vector design. The research addresses critical inefficiencies in AAV-mediated gene therapy. Current AAV vectors suffer from poor genome packaging efficiency mediated...
- The National Institute of Allergy and Infectious Diseases awarded Western University of Health Sciences $200,600 on August 7, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate noncanonical DNA virus sensing through an IKK-alpha-driven interferon signaling cascade. The research project maps a previously unrecognized antiviral signaling pathway that bypasses the canonical cGAS-STING-TBK1-IRF3 axis and instead utilizes IKK-alpha to drive type I interferon...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Arkansas for Medical Sciences $420,335 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 23, 2025, for a project period extending through May 31, 2027. The project investigates the role of lytic viral genes in the pathogenesis of oncogenic gammaherpesviruses, specifically examining whether lytic gene expression drives the development and...
- The National Institute of Allergy and Infectious Diseases, a division of the Department of Health and Human Services, awarded the University of Florida Division of Sponsored Research $392,142 on February 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop nanoparticle therapeutics for inflammatory bowel disease. The award funds development of an off-the-shelf therapeutic approach using polysaccharide A (PSA)–derived nanoparticles from commensal...
The National Institute of Allergy and Infectious Diseases awarded the University of Florida $219,532 on August 20, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate a noncanonical STING-dependent, interferon-I-independent antiviral pathway against Kaposi's sarcoma-associated herpesvirus reactivation. The project addresses mechanisms by which the STING pathway restricts KSHV reactivation despite the virus's ability to suppress type I interferon production. Using genetic models and STING agonists, the research identifies interferon regulatory factor transcription factors and interferon-stimulated genes as critical mediators of antiviral defense under interferon-I deficiency. The work aims to define molecular components of this noncanonical pathway and identify therapeutic strategies to limit KSHV-associated cancers, including Kaposi sarcoma and primary effusion lymphoma. The University of Florida Division of Sponsored Research is the recipient. Performance occurs in Gainesville, Florida, with a period of performance from August 20, 2026, through July 31, 2028. This project grant is assistance funding, not a procurement contract.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $219.5k | 8/20/26 |