Project Grant R21AI202284
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University a $1,279,395 cooperative agreement on August 1, 2026, to investigate fundamental mechanisms governing the induction of antigen-specific IgA in the gastrointestinal tract under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research project examines two distinct pathways generating affinity-matured gut IgA following oral immunization with protein antigens. The first pathway,...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $493,889 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate mechanisms of food-specific antibody induction in the gut. The research will elucidate how invariant natural killer T cells, type 2 conventional dendritic cells, and T follicular helper cells work in concert to promote production of food-specific immunoglobulin E antibodies, using a mouse model...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $334,649 on July 20, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate fetal adaptive immune responsiveness in preterm premature rupture of membranes. The research measures whether the fetal adaptive immune system, traditionally considered inert or tolerogenic, mounts a response to ascending bacterial infection following membrane rupture. The project focuses on...
- The National Institute of Allergy and Infectious Diseases awarded The University of Chicago $1,177,657 on July 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the biophysical and structural basis of T cell selection at the intersection of conventional and regulatory T cell repertoires. The research addresses autoimmune disease pathogenesis by examining how CD4+ T cells recognize peptide antigens complexed with MHC class II molecules through the T...
- The National Institute of Allergy and Infectious Diseases awarded Loyola University of Chicago Health Sciences Campus $462,000 on August 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on mechanistic understanding of influenza virus inhibition by non-canonical ISG15. The research examines how alternative splicing of the interferon-stimulated gene ISG15 produces novel transcript isoforms that inhibit influenza virus replication. The project...
- The National Institute of Allergy and Infectious Diseases awarded The University of Chicago $667,630 on July 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to fund research decoding gamma-delta T cell selection and functional maturation through IL17RA, identified as a novel superantigen-like gamma-delta T cell receptor ligand. The project investigates endogenous ligands that shape gamma-delta T cell repertoire, functional properties, and tissue localization....
- The National Institute of Allergy and Infectious Diseases awarded The Feinstein Institutes for Medical Research $460,625 on February 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the maturation and maintenance of the germinal center niche, specifically follicular dendritic cells (FDCs). The research determines FDC longevity and turnover in young and aged mice at steady state, post-immunization, and under chronic lupus inflammatory conditions,...
- The National Institute of Allergy and Infectious Diseases awarded Ann & Robert H Lurie Children's Hospital of Chicago $3,157,631 on September 10, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to refine and validate a symptom report-based food allergy prevalence questionnaire for population-based studies. The award funds development of a refined survey instrument to estimate IgE-mediated food allergy burden in the U.S. pediatric and adult populations. Work...
- The National Institute of Allergy and Infectious Diseases awarded Rush University Medical Center $269,500 on June 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to assess the role of HIV-specific IgA glycosylation on transport and function as a foundation for anti-HIV IgA immunotherapy. The research will characterize glycosylation patterns of bulk IgA isolated from people living with HIV and compare them to non-HIV controls, assessing how these glycosylation...
- The National Institute of Allergy and Infectious Diseases awarded La Jolla Institute for Immunology (doing business as La Jolla Institute for Allergy & Immunology) $764,868 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate house dust-mite allergen-specific T cell subsets in allergy and asthma. The research explores mechanisms and cell types that drive either natural tolerance or allergen sensitization and asthma development, focusing on...
The National Institute of Allergy and Infectious Diseases awarded Loyola University of Chicago Health Sciences Campus $223,068 on August 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate affinity maturation mechanisms in ectopic lymphoid tissues formed in allergic lungs. The research will identify molecular features—including activation-induced cytidine deaminase (AID) expression, somatic hypermutation, and clonal selection—that drive affinity maturation in lung ectopic lymphoid tissues, and determine which cell types capture antigens and provide survival signals to germinal center B cells within those tissues. The work addresses how inhaled allergens induce persistent ectopic lymphoid tissues that boost generation of antigen-specific antibodies upon allergen re-encounter, with implications for understanding local antibody responses in allergic asthma and other conditions involving ectopic lymphoid tissue formation. Performance occurs in Maywood, Illinois from August 10, 2026 through July 31, 2028. This is a Project Grant, classified as assistance funding to a nonprofit academic medical center division conducting biomedical research in immunology and infectious disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $223.1k | 8/10/26 |