Project Grant R21AI202047
- The National Institute of Allergy and Infectious Diseases awarded the University of Washington $256,074 on June 4, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to optimize and advance preclinical development of an immunotherapeutic targeting CD8 T cells for genital herpes caused by herpes simplex virus infection. The award funds research to boost the levels and localization of HSV-specific CD8 T cells, with the objective of achieving a functional cure for...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded $902,741 to the University of Washington on July 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds basic research into the cell type-specific regulation of STING signaling, a central pathway in innate immune response with implications for antiviral immunity, antitumor immunity, and aging-associated inflammation. The research investigates why STING activation produces...
- The National Institute of Allergy and Infectious Diseases awarded Washington State University $618,650 on August 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on ZBP1 signaling in respiratory syncytial virus (RSV) triggered host defense and pathogenesis. The research examines how RSV activates the immune sensor protein ZBP1, which triggers necroptosis in infected stromal cells and pyroptosis in myeloid cells. The project investigates...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded Emory University $100,228 on November 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into autoreactive, extrafollicular B cell pathways in a TLR7-driven murine model. The project addresses gaps in understanding the origins of extrafollicular effector B cells and the system-wide and microenvironmental signaling that...
- The National Institute of Allergy and Infectious Diseases awarded $264,750 to the University of Washington on August 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of three transcriptional regulators—DR1, DRAP1, and BTAF1—in suppressing interferon responses triggered by self-RNA ligands. The research characterizes how loss of these proteins induces robust interferon responses and explores the immunostimulatory double-stranded RNA...
- The National Institute of Allergy and Infectious Diseases awarded Seattle Children's Hospital $911,271 on August 4, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate mechanisms regulating integration of engineered B cells in intestinal immunity and inflammation. The research aims to develop a B cell-based immunotherapy platform for treatment of inflammatory bowel disease and related immune-mediated diseases. The project focuses on long-lived plasma...
- The National Institute of Allergy and Infectious Diseases awarded Fred Hutchinson Cancer Center $238,899 on June 8, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct preclinical evaluation of human monoclonal antibodies for herpes simplex virus type 2 (HSV-2) therapeutics. The research isolates and characterizes antibody-secreting cells discovered in genital skin tissue up to four months following HSV lesion healing. The project involves comprehensive...
- The National Institute of Allergy and Infectious Diseases awarded Kaiser Foundation Hospitals $825,617 on August 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to evaluate long-term effectiveness of recombinant zoster vaccine (RZV) against herpes zoster and postherpetic neuralgia. The award funds a longitudinal observational study assessing RZV effectiveness over time in real-world populations, addressing a gap in evidence where clinical trials have...
- The National Institute of Allergy and Infectious Diseases awarded The University of Texas Southwestern Medical Center $249,000 on July 20, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research to develop tools for marginal zone-specific gene expression manipulation in B cells. The project investigates how mature B cell subsets—follicular, marginal zone, and B-1 cells—contribute to protective immune responses in infection and pathogenic responses...
- The National Institute of Allergy and Infectious Diseases awarded the University of Washington $804,183 on July 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to design bifunctional chimeric proteins that redirect immune responses against antibiotic-resistant bacterial pathogens. The project applies deep learning-enabled protein design to create bacterial targeting chimeras (BacTACs) that simultaneously bind surface proteins on antibiotic-resistant bacteria...
The National Institute of Allergy and Infectious Diseases awarded the University of Washington $264,750 on August 13, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate local B cell immune response to varicella zoster virus infection in shingles patients. The research examines antibody-secreting cells present in shingles lesions, focusing on characterizing virus-specific human monoclonal antibodies derived from tissue biopsies. Prior single-cell RNA sequencing and B cell receptor sequencing of shingles biopsies identified abundant antibody-secreting cells with high somatic hypermutation indicative of local B cell response to VZV. The investigators have expressed over 40 local B cell receptors as recombinant IgG and identified VZV-specific antibodies in six of eight subjects studied, with approximately two-thirds of tested human monoclonal antibodies showing VZV specificity. The work explores tertiary lymphoid structures—aggregates of T, B, and other immune cells—that form at the site of pathogen challenge, and evaluates some local monoclonal antibodies for their capacity to inhibit VZV cell-to-cell spread and recognize known neutralizing antibody targets. The award is structured as a Project Grant, a competition-based assistance type. Period of performance runs from August 13, 2026, through July 31, 2028, with place of performance at the University of Washington in Seattle, Washington. The University of Washington's Office of Sponsored Programs administers the award.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $264.8k | 8/13/26 |