Project Grant R21AI201898
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded the University of Wisconsin–Madison a $415,360 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) effective August 1, 2026, with completion targeted for March 31, 2031. This award funds fundamental research to understand the roles of giant starship transposons in horizontal gene transfer and fungal evolution. The research will characterize previously undiscovered...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $146,920 to the University of Wisconsin-Madison under the Allergy and Infectious Diseases Research program (CFDA 93.855) on November 30, 2025, with completion anticipated by May 31, 2027. This project grant supports fundamental research to elucidate the molecular mechanisms governing polyspecific drug efflux in bacterial multidrug resistance pumps, addressing the critical public health...
- Federal Grant Award Summary The University of Wisconsin–Madison received a $213,811 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded May 1, 2026, with completion targeted for April 30, 2028. The project develops a novel therapeutic approach to treat Aspergillus fumigatus infections—a leading cause of mortality in immunocompromised transplant patients—by engineering chimeric...
- Federal Grant Award Summary The University of Wisconsin–Madison received a $791,200 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 1, 2026 through June 30, 2031. This award supports the development and optimization of novel inhibitor compounds targeting Naegleria fowleri, a parasitic amoeba that causes primary amebic meningoencephalitis with a mortality rate...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Wisconsin–Madison a Project Grant of $422,814 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 25, 2025, with a completion date of May 31, 2027. The award funds the development and application of adversarial machine learning methods to predict viral spillover risk—specifically, to identify which animal viruses are likely to infect humans and...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $414,305 Project Grant to the University of Wisconsin–Madison on February 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This award supports a multipronged research initiative characterizing the substrate promiscuity and transport mechanism of PACE (Proteobacterial Antiseptic Efflux) family transporters through a two-year performance period ending...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded University of Wisconsin–Madison a $475,681 Project Grant effective February 1, 2026, through January 31, 2031, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds development and validation of novel analytical tools to elucidate the functional roles, protein interactions, and cellular localization patterns of HIV-1 alternatively spliced transcripts....
- Federal Project Grant Award Summary The University of Wisconsin–Madison received a $1.59 million project grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 1, 2026, with completion expected June 30, 2030. This biomedical research grant funds a four-year investigation into the role of cyclic di-adenosine monophosphate (c-di-AMP) in Listeria monocytogenes pathogenesis. The project...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $713,383 Project Grant to the Regents of the University of Minnesota on July 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research through June 30, 2031. The research focuses on investigating the mechanisms and dynamics of genome plasticity in Candida species, particularly in the context of antifungal drug resistance. The project will employ...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Wisconsin–Madison a $427,625 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, through July 31, 2027. The award supports research and development activities focused on creating an innovative probiotic-based therapeutic delivery system. The project centers on developing plasmid-independent, carbohydrate-regulated...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded University of Wisconsin–Madison a $272,125 Project Grant (CFDA 93.855: Allergy and Infectious Diseases Research) effective July 7, 2026, with completion targeted for June 30, 2028. The award funds research investigating the evolutionary origins and consequences of starship-mediated variation in fungi, with a focus on understanding how giant transposons called starships generate phenotypic variation in fungal pathogens and facilitate horizontal transfer of adaptive traits. This research addresses a critical clinical challenge: substantial phenotypic variation within fungal species that complicates standardized treatment approaches for life-threatening fungal infections. The funded research employs the opportunistic fungal pathogen Aspergillus fumigatus as a model organism to determine the evolutionary mechanisms and transmission routes of starships. Aim 1 will assess whether starship-associated gene paralogs generate greater phenotypic divergence compared to genomic paralogs by comparing transcriptomic, metabolomic, and morphological phenotypes within the LAEA-like methyltransferase family. The project will deliver scientific findings characterizing starship-mediated generation of evolutionary novelty and the molecular mechanisms underlying starship-driven variation in fungal populations—deliverables intended to advance understanding of unconventional evolutionary processes and inform strategies for managing phenotypic variation in fungal pathogens.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $272.1k | 7/7/26 |