Project Grant R21AI200130
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $444,125 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 1, 2026 through March 31, 2028. The award funds research to accelerate immune system reconstitution following cultured thymus tissue implantation (CTTI), also known as thymus transplantation. The research team...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $626,475 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) on June 15, 2026, with completion targeted for May 31, 2031. The award supports fundamental research investigating the role of integrin alpha-6 (A6) in breast cancer leptomeningeal metastasis—a rapidly fatal condition involving tumor spread to the cerebrospinal fluid-containing...
- Federal Grant Award Summary Duke University received a $2.89 million Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) awarded August 1, 2025, with completion scheduled for July 31, 2029. This research project, titled "Understanding and Targeting Epigenetic Regulation of Immune Evasion in Prostate Cancer," will investigate how epigenetic mechanisms—specifically through the TNRC18 protein—regulate immune evasion in...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $415,257 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective July 3, 2025, with completion targeted for June 30, 2027. This research initiative focuses on developing novel chimeric antigen receptor (CAR) T-cell therapies by harnessing B cells from patients following stem cell transplantation for hematological malignancies...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $171,269 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective November 1, 2025, with a completion date of April 30, 2028. The award funds research investigating the role of the RGS12 (Regulators of G-Protein Signaling 12) locus in macrophage function, specifically examining how...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $175,928 Project Grant award from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective January 18, 2026, with a completion date of January 17, 2027. This award funds basic biomedical research training and scientific investigation into the mechanisms of small nucleolar RNA SNORD67 in breast cancer lymphatic metastasis. The research addresses how...
- Federal Project Grant Award Summary Duke University's Office of Research Administration was awarded $845,250 by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) beginning July 1, 2025, through June 30, 2028. The project focuses on engineering T-cell receptor (TCR)-modified T cells designed to target human endogenous retroviruses for non-small cell lung cancer immunotherapy. This research initiative represents an advanced biomedical research...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $242,250 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 13, 2026, with completion targeted for January 31, 2028. The award funds research to develop prognostic biomarkers for invasive candidiasis through analysis of host gene expression patterns in circulating immune cells. The...
- Federal Grant Award Summary Duke University's Office of Research Administration has been awarded $395,846 by the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) for the project period April 1, 2026 through March 31, 2031. This Project Grant supports research on therapeutic targeting of SMARCAL1 (an annealing helicase protein) as a synthetic lethal vulnerability in alternative lengthening of telomeres (ALT)-positive cancers, particularly IDH-mutant...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $1.23 million Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective June 16, 2026 through May 31, 2031. This grant funds preclinical research to develop donor-specific transplant tolerance strategies, with the goal of reducing the need for organ retransplantation and preventing...
Duke University's Office of Research Administration received a $242,250 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective June 22, 2026, with completion targeted for May 31, 2028. The award funds research conducted in Durham, North Carolina, investigating novel mechanisms by which regulatory T cells (Tregs) suppress anti-breast cancer immunity. The research aims to characterize and functionally target a previously unexplored molecular complex involving an RNA helicase and the spliceosome that enables Treg-mediated immune suppression in tumors. The funded research will deliver foundational scientific insights into Treg biology and generate preclinical evidence supporting new immunotherapeutic strategies for breast cancer patients, particularly those resistant to current treatments. Preliminary studies in mouse models have demonstrated that disrupting the identified molecular partnership in Tregs produces potent anti-tumor immune responses and halts tumor progression, positioning this work to inform the development of novel therapeutic interventions that enhance natural anti-tumor immunity and improve clinical outcomes for breast cancer patients.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $242.3k | 6/23/26 |