Project Grant R21AI200125
- Federal Grant Award Summary Award Details: The National Institute of Allergy and Infectious Diseases (NIAID) awarded Tufts University School of Medicine a Project Grant totaling $1,294,374 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 3, 2025, with a completion date of June 30, 2030. Research Scope: This award funds investigation into the role of heme synthesis in controlling regulatory T cell (Treg) fitness and function, with the objective of developing...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of California, Irvine a Project Grant of $431,750 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period February 1, 2026 through January 31, 2028. This research initiative focuses on investigating the functional expansion of regulatory T (Treg) cells to limit central nervous system (CNS) autoimmunity and promote myelin repair. The research...
- Federal Grant Award Summary This Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports a five-year research initiative focused on understanding the molecular mechanisms of thymic T cell tolerance and autoimmune disease. The University of California, San Francisco received $201,744 on June 4, 2026, to conduct investigator-initiated biomedical research under Dr. Nielsen's...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded the University of New Mexico Health Sciences Center a Project Grant of $456,328 on September 15, 2025, under the Environmental Health program (CFDA 93.113) to investigate patterns of autoimmune biomarkers among Native American and Alaska Native tribal members exposed to metals, metalloids, and organochemicals. The two-year project (completion date September 14, 2027) will establish a...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $794,183 Project Grant to the Beckman Research Institute of the City of Hope for research investigating the role and regulation of methylarginine effector TDRD3 (Tudor domain-containing protein 3) in T cell immunity. The award, issued April 8, 2026, with a completion date of March 31, 2031, is funded under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the Regents of the University of Minnesota a Project Grant totaling $1,315,346 under the Allergy and Infectious Diseases Research program (CFDA 93.855) beginning July 22, 2025, with an ultimate completion date of June 30, 2030. The research initiative investigates non-deletional CD8+ T cell tolerance mechanisms to prevent autoimmune disease. The project delivers mechanistic research...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Feinstein Institutes for Medical Research a Project Grant of $209,375 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on April 23, 2026. The project, scheduled for completion by March 31, 2028, will investigate the role of autophagy in B cell tolerance loss, with particular focus on how autophagy defects contribute to autoimmune disease pathogenesis,...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Maryland, College Park a $722,262 Project Grant (CFDA 93.855 – Allergy and Infectious Diseases Research) on February 19, 2026, to develop and evaluate a novel microneedle array delivery system designed to promote antigen-specific immune tolerance in autoimmune diseases. The research addresses significant limitations of existing immunosuppressive therapies by pursuing a...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Utah $743,752 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct a five-year investigator-initiated research project beginning August 1, 2025 and concluding July 31, 2030. This Project Grant supports fundamental biomedical research investigating the epigenetic mechanisms that govern CD4+ helper T cell dysfunction during chronic viral infections....
- Federal Project Grant Award Summary The University of Texas MD Anderson Cancer Center received a $5.92 million Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025, through July 31, 2029. This award supports investigator-initiated biomedical research examining the role of GRAIL (Gene Related to Anergy in Lymphocyte), an E3 ubiquitin ligase gene, in B cell...
The National Institute of Allergy and Infectious Diseases awarded the University of New Mexico Health Sciences Center a Project Grant totaling $228,750 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 17, 2026, with completion scheduled for May 31, 2028. This research initiative focuses on investigating how trichloroethylene (TCE), an industrial solvent and environmental contaminant, impairs immune tolerance mechanisms and contributes to autoimmune disease development. The project specifically examines how TCE and its metabolite TCAH deliver costimulatory signals to autoreactive CD4+ T cells in the liver, thereby disrupting normal tolerance pathways that typically suppress self-reactive immune responses. The research deliverables consist of two primary aims: (1) assessing TCE's real-time effects on recent thymic emigrant (RTE) CD4+ T cell migration patterns in transgenic mice, and (2) investigating TCAH-mediated costimulatory signaling in CD4 RTEs through in vitro experiments. Upon completion, these studies will establish the mechanistic basis for how TCE alters key hepatic tolerance pathways, contributing to a greater proportion of self-reactive effector memory CD4+ T cells capable of promoting autoimmune disease development. This research addresses a significant gap in understanding environmentally induced autoimmunity and advances knowledge in both toxicology and immunology disciplines.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $228.8k | 6/17/26 |