Project Grant R21AI199678
- The National Institute of Allergy and Infectious Diseases awarded Louisiana State University $599,480 on June 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the regulation of neutrophil endoplasmic reticulum stress response by IRE1A in bacterial lung infection. The research addresses innate immune mechanisms that defend against methicillin-resistant Staphylococcus aureus (MRSA) lung infection, a drug-resistant pathogen causing mortality rates up...
- The National Institute of Allergy and Infectious Diseases, an operating division of the Department of Health and Human Services, awarded Louisiana State University $412,500 on February 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify RNAi-independent antiviral genes through biased genetic screening in Caenorhabditis elegans. The funded research addresses antiviral mechanisms that function independently of RNAi (RNA interference), the predominant...
- The National Institute of Allergy and Infectious Diseases awarded $233,250 to the University of Maryland, Baltimore on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to fund research on how Rickettsia species manipulate macrophage antimicrobial responses through engagement of the CD300F efferocytic receptor to facilitate host infection. The research addresses the gap in understanding rickettsial pathogenesis mechanisms that has hindered development of...
- The National Institute of Allergy and Infectious Diseases awarded Louisiana State University Health Sciences Center-Shreveport $660,723 on April 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of Z-form nucleic acid binding protein 1 (ZBP1) in controlling herpes simplex virus type 1 (HSV-1) pathogenesis. The research will identify Z-RNA ligands that activate ZBP1 during HSV-1 infection and determine how these ligands form in infected...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $440,000 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Texas Medical Branch at Galveston for a two-year project period (August 1, 2025 – July 31, 2027). This Project Grant funds biomedical research investigating the pathogenic mechanisms of rickettsioses, devastating human infections that disproportionately affect microvascular...
- The National Institute of Allergy and Infectious Diseases awarded Louisiana State University Health Sciences Center-Shreveport $513,411 on June 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how eosinophils promote persistence and transmission of Bordetella species infections. The research dissects the role of eosinophils in enabling Bordetella persistence and transmission through two specific aims. Aim 1 delineates the immunosuppressive...
- The National Institute of Allergy and Infectious Diseases awarded Massachusetts Institute of Technology $185,472 on August 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on molecular host determinants of spotted fever group rickettsial infection. The funded research addresses host-pathogen interactions in Rickettsia species, obligate intracellular bacterial pathogens that cause tickborne vascular endothelial diseases with rising global...
- The National Institute of Allergy and Infectious Diseases awarded William Marsh Rice University $422,698 on February 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to explore how the innate immune system shapes the adaptation of emergent and pre-emergent opportunistic pathogens. The research uses a high-throughput approach combining microfluidics, in vitro experimental evolution, and genomic and phenotypic characterization to investigate microbial emergence and...
- The National Institute of Allergy and Infectious Diseases awarded Louisiana State University Health Sciences Center-Shreveport $442,500 on August 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research on the essential functions of alveolar epithelial cells in tuberculosis pathogenesis. The research addresses mechanisms of tuberculosis-associated lung damage. The project investigates how Mycobacterium tuberculosis infection compromises alveolar...
- The National Institute of Allergy and Infectious Diseases awarded Old Dominion University $1.322 million in funding on April 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate mechanisms by which pathogenic Rickettsia species manipulate macrophage mitochondrial function and evade host immune responses. The award funds two research aims: determining how pathogenic spotted fever group rickettsia remodel mitochondrial dynamics in macrophages through...
The National Institute of Allergy and Infectious Diseases awarded Louisiana State University $219,174 on September 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate endoplasmic reticulum stress responses in Rickettsia pathogenesis. The research examines how pathogenic Rickettsia species—obligate intracellular gram-negative proteobacteria including R. rickettsii, R. conorii, and R. parkeri—trigger endoplasmic reticulum stress and proteasome-related changes within infected host cells to establish conditions favorable to rickettsial proliferation. The project focuses on the role of IRE1-dependent signaling and downstream intermediates in facilitating intracellular bacterial replication, using pharmacological approaches to test mechanistic hypotheses developed from prior transcriptomic and proteomic studies in infected macrophages. Performance occurs in Baton Rouge, Louisiana from September 2, 2026 through August 31, 2028. The award is classified as a Project Grant with total obligation of $219,174.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $219.2k | 9/2/26 |