Project Grant R21AI196898
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $194,940 to the University of Pennsylvania under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 12, 2025, with completion targeted for July 31, 2030. This research initiative focuses on identifying and characterizing human genetic regulators of macrophage antimicrobial responses to Mycobacterium tuberculosis (MTB) infection. The project builds...
- Federal Grant Award Summary The University of Pennsylvania received a $446,875 Project Grant awarded on August 26, 2025, by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports a longitudinal cohort study investigating fibroblast activation protein (FAP) positron emission computed tomography (PET/CT) imaging as a novel diagnostic and monitoring approach for tuberculosis-associated lung...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Pennsylvania $3,204,624 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 24, 2025, to conduct a four-year research project examining non-canonical inflammasome responses to lipopolysaccharide (LPS) in human and mouse models. This fundamental research initiative will investigate the molecular and cellular mechanisms by which caspase-11 (CASP11) in...
- Federal Grant Award Summary Temple University received a $683,299 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 5, 2025, with completion targeted for June 30, 2029. The grant funds research examining functional immune phenotyping in sepsis patients through an integrated approach combining microphysiological assays, omics analysis, and computational modeling. The research specifically...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Tufts University School of Medicine a $450,630 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, through July 31, 2027. This award supports spatiotemporal investigation of interactions between pneumolysin, pulmonary epithelium, and polymorphonuclear neutrophils (PMNs) to elucidate age-associated susceptibility to...
- Federal Project Grant Award Summary Tufts University School of Medicine received a $156,080 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded January 29, 2026, with completion targeted for August 15, 2028. The grant funds research investigating the spatio-temporal modulation of innate immune cells in relation to Mycobacterium tuberculosis (MTB) stress response and replication...
- Federal Grant Award Summary The University of Pennsylvania received a $822,015 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 6, 2025, with completion targeted for July 31, 2026. This award funds the development of novel statistical methodology to address methodological challenges in infectious disease research, specifically the concurrent presence of network dependence,...
- Federal Grant Award Summary Towson University received a $149,620 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025, through July 31, 2029. The grant supports research investigating the NADase (nicotinamide adenine dinucleotide hydrolase) function of bacterial Toll/Interleukin-1 Receptor (TIR) domain-containing proteins, specifically examining how TIR proteins'...
- Federal Project Grant Award Summary The University of Pennsylvania received a $109,076 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective January 23, 2026, with a completion date of August 31, 2029. This award supports investigative research focused on T cell trafficking mechanisms during Cryptosporidium infection, an apicomplexan parasite that represents a leading cause of...
- Federal Project Grant Award Summary The Pennsylvania State University received a $385,625 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 7, 2025, with completion targeted for June 30, 2027. The award supports the systematic evaluation and development of novel polymeric micelle therapeutics designed to inhibit inducible nitric oxide synthase (iNOS) and nitric...
Temple University-Of The Commonwealth System Of Higher Education received a $435,875 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 10, 2026, with a completion date of January 31, 2028. The award supports biomedical research investigating eicosanoid roles in mucosal immunity during influenza and Staphylococcus aureus superinfection using advanced laboratory methodologies. The research deliverables center on understanding why the immune system fails to prevent severe bacterial superinfections following viral illness, with specific focus on how cytochrome P450 (CYP450)-derived lipids and the protein PPARA (peroxisome proliferator-activated receptor alpha) disrupt lung mucosal immunity. The project employs two cutting-edge approaches—spatial transcriptomics and lung-on-a-chip technology—to characterize eicosanoid molecular mechanisms and immune cell behavior at the cellular level. Research outcomes are anticipated to advance scientific knowledge of infection pathogenesis and identify potential therapeutic targets for preventing or mitigating bacterial superinfection complications, particularly relevant to antibiotic-resistant pathogens. The work will be conducted at Temple University's Philadelphia, Pennsylvania location.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $435.9k | 2/10/26 |