Project Grant R21AI196663
- Federal Project Grant Award Summary Oregon Health & Science University (OHSU) received a Project Grant award of $622,130 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 21, 2025, with a completion date of July 31, 2030. The award supports fundamental research investigating how pathogenic bacteria manipulate atypical ubiquitin signaling pathways to exploit host cell processes....
- Federal Project Grant Award Summary Oregon State University received a $408,375 Project Grant award on July 14, 2025, from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on phage-antibiotic combination therapies for treating Mycobacterium abscessus (MAB) infections. The research deliverables focus on identifying and characterizing MAB surface targets involved in phage resistance mechanisms and...
- Federal Project Grant Award Summary Oregon Health & Science University received $743,817 in funding from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 12, 2025, for a project extending through July 31, 2030. The project focuses on identifying and characterizing T cell receptor (TCR) families associated with protection from tuberculosis (TB) infection and disease progression, with particular...
- Federal Grant Award Summary Oregon State University received a $392,747 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 17, 2025, with completion targeted for June 30, 2027. The grant supports research into the biosynthesis and self-resistance mechanisms of kibdelomycin, a natural product antibiotic candidate with a novel binding motif to DNA gyrase. The research...
- Federal Grant Award Summary Oregon Health & Science University (OHSU) received a $1,174,636 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective May 1, 2025, through April 30, 2029. The grant supports research and development of next-generation endochin-like quinolone (ELQ) compounds for the treatment and prevention of malaria. The primary deliverable is the advancement...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Medical University of South Carolina (MUSC) a Project Grant totaling $240,878 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 2, 2025, with completion targeted for May 31, 2026. This R34 Clinical Trial Planning Grant supports development of a randomized, controlled clinical trial evaluating novel treatment strategies for Mycobacterium abscessus complex (MABC)...
- Federal Grant Award Summary Oregon State University received a $495,688 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 2, 2026, through January 31, 2031. The award supports mechanistic and structural studies on the biosynthesis of ureido-containing natural products, specifically investigating ureido bond formation in three families of bioactive bacterial natural...
- Federal Grant Award Summary Oregon Health & Science University received a $2,989,013 Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 13, 2025, with completion targeted for July 31, 2029. The grant supports research characterizing newly identified human cytomegalovirus (HCMV) entry receptors in epithelial and endothelial cells. The research leverages novel receptor capture...
- Federal Project Grant Award Summary Oregon Health & Science University (OHSU) received a $195,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 6, 2026 through January 31, 2028. The grant supports investigator-initiated biomedical research focused on understanding the relationship between sphingolipids (particularly ceramide) and innate antiviral immunity....
- Federal Grant Award Summary Oregon Health & Science University (OHSU) received a $482,625 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 1, 2026, through January 31, 2028. This award supports the development and evaluation of long-acting antiretroviral therapy (LA-ART) as a therapeutic alternative to daily antiretroviral treatment (ART) regimens in simian...
Oregon Health & Science University received a $442,758 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 9, 2026, with completion targeted for January 31, 2028. The project, titled "Identifying Drug Targets in M. abscessus Through the Application of Fluorescent Probes," will deliver comprehensive research data characterizing the mechanism of action for dual beta-lactam antibiotic therapy against Mycobacterium abscessus (MAB), a non-tuberculous mycobacterium with inherent antibiotic resistance and high treatment failure rates. The research deliverables include scientific evidence documenting how dual beta-lactam treatment synergistically inhibits multiple enzymatic targets involved in mycobacterial cell wall biosynthesis, addressing a critical gap in clinical understanding that currently limits physician adoption of this therapeutic approach. This exploratory research (R21 mechanism) will generate mechanistic data necessary to support clinical guideline updates and inform development of more effective treatment strategies for patients with difficult-to-treat MAB pulmonary infections, where existing FDA-approved therapeutic options remain unavailable.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $442.8k | 2/9/26 |