Project Grant R21AI196548
- Federal Grant Award Summary The University of Pittsburgh has received a $430,170 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), with an award date of July 9, 2025 and completion deadline of June 30, 2027. This project will deliver research services focused on identifying viral genetic determinants of Enterovirus D68 (EV-D68) neuropathogenesis using an innovative human spinal cord...
- Federal Project Grant Award Summary The University of Pittsburgh received a $691,788 Project Grant award dated July 25, 2025, from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award, with an ultimate completion date of June 30, 2030, supports investigator-initiated biomedical research focused on understanding and controlling the Epstein-Barr virus (EBV) life cycle in B cell and epithelial cell...
- Federal Grant Award Summary The University of Pittsburgh received a $790,847 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 10, 2026, with completion targeted for January 31, 2031. This award supports comprehensive research investigating HIV-1 resistance pathways against lenacapavir (LEN), a potent capsid inhibitor under investigation for both treatment and...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Kansas Center for Research Inc. a Project Grant of $411,499 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, with completion scheduled for July 31, 2027. This research project seeks to establish poly(ADP-ribose) polymerase 14 (PARP14) as a novel host restriction factor that limits Herpes Simplex Virus 1 (HSV-1)...
- Federal Project Grant Award Summary The University of Pittsburgh received a $634,981 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on June 17, 2025, with a completion date of May 31, 2030. This award supports research investigating the role of Merkel Cell Polyomavirus (MCV) small T antigen in persistent viral infection and its relationship to Merkel Cell Carcinoma development....
- Federal Grant Award Summary The University of Pittsburgh received a $433,710 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), with funding obligated on February 15, 2026, and a project completion date of January 31, 2028. The grant supports the development and refinement of epigenetically optimized, replication-defective herpes simplex virus (RDHSV) vectors as a novel gene therapy platform for treating Alzheimer's disease (AD). The...
- Federal Grant Award Summary The University of Pittsburgh received a $412,942 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 5, 2026, with completion targeted for January 31, 2028. This developmental research initiative investigates the regulatory mechanisms by which host-derived environmental signals in the gastrointestinal tract control hypervirulent Klebsiella...
- Federal Grant Award Summary The University of Pittsburgh received a $430,760 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 10, 2025, with completion scheduled for June 30, 2027. The project, titled "Training of Neutrophils to Defend Against a Lethal Bacterial Infection of the Lung," focuses on developing immunological strategies to enhance host defense against...
- Federal Project Grant Award Summary The University of North Carolina at Chapel Hill received a $427,625 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 6, 2026 through January 31, 2028. This award supports the development of a novel lateral flow strip assay (LFSA) device designed to provide rapid point-of-care diagnostic testing for herpes simplex virus (HSV)...
- Federal Project Grant Award Summary The University of Pittsburgh received a $556,843 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 16, 2025, with a completion date of June 30, 2030. This grant supports basic immunology research investigating the development and regulation of the extrafollicular (EF) B cell response as a programmed immune response type. The research aims...
The University of Pittsburgh received a $250,682 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 19, 2026, with completion by January 31, 2028. This award funds investigative research examining the role of nuclear paraspeckles and speckles in regulating Herpes Simplex Virus-1 (HSV-1) infection in human neurons, with particular emphasis on their contribution to viral latency establishment and maintenance. The funded research delivers two primary research products: (1) investigation of whether silencing paraspeckle-associated genes (NEAT1, PSPC1, NONO, and SFPQ) prevents HSV-1 lytic gene silencing and inhibits productive viral infection in induced pluripotent stem cell (iPSC)-derived neuronal models of HSV-1 latency; and (2) exploration of nuclear speckle and paraspeckle involvement in epigenetic modifications of HSV-1 chromatin underlying latency establishment. The research outcomes are designed to provide mechanistic insights into paraspeckle regulation of HSV-1 infection in human neurons, thereby advancing foundational knowledge applicable to future therapeutic development and clinical applications in infectious disease treatment.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $250.7k | 2/17/26 |