Project Grant R21AI195633
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $234,750 to the University of Notre Dame DU Lac under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 15, 2025, for an exploratory research project extending through June 30, 2027. This R21 grant funds scientific investigation into polymicrobial interactions during catheter-associated urinary tract infections (CAUTIs), specifically examining cross-kingdom...
- Federal Project Grant Award Summary Marshall University Research Corporation received a $221,250 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 1, 2026 through June 30, 2028. The grant funds research to develop a novel metabolic-immune adjunctive therapy for necrotizing fasciitis caused by Streptococcus pyogenes (Group A Streptococcus). The research will investigate...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Miami's Office of Research Administration - School of Medicine Division a $617,438 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective April 1, 2026 through March 31, 2030. This award supports the development of a rapid, cell-based point-of-care diagnostic platform for urinary tract infection (UTI) diagnosis and antibiotic...
- Federal Project Grant Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $234,000 Project Grant to the University of South Alabama on May 7, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This R21 exploratory research grant, concluding April 30, 2028, funds a novel investigation into the pathogenic role of amyloid-beta (Aβ) peptides in urinary tract infection (UTI) progression and kidney injury. The research addresses a critical...
- Federal Project Grant Award Summary The University of Washington received a $777,498 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective May 12, 2026, with completion targeted for April 30, 2031. The project focuses on developing novel therapeutic mechanisms to inhibit bacterial adhesion by characterizing parasteric inhibition of FimH, the primary adhesin of uropathogenic...
- Federal Grant Award Summary The University of Notre Dame received a $614,655 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 1, 2026, with performance through June 30, 2031. This five-year research initiative focuses on understanding the bladder inflammatory and immune responses to fungal catheter-associated urinary tract infections (CAUTIs) caused by Candida albicans....
- Federal Grant Award Summary Princeton University's Office of Research and Project Administration received a $451,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 23, 2025, with completion targeted for June 30, 2027. The research initiative employs chemical synthetic lethality methodology to identify novel antimicrobial targets in gram-negative bacterial...
- Federal Grant Award Summary Award Overview The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Massachusetts a $2.64 million Project Grant on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop antimicrobial polymer therapeutics for treating multidrug-resistant (MDR) wound biofilm infections. The four-year award, scheduled for completion on March 31, 2030, integrates synthetic chemistry, computational...
- Federal Grant Award Summary Award: Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) Funding Amount and Timeline: $254,250 obligated for the period July 1, 2026 through June 30, 2028 Products and Services: This two-year research project, conducted by New York University School of Medicine, focuses on investigating the epigenetic mechanisms and evolutionary generality of bacterial...
- Federal Project Grant Award Summary The University of Florida Division of Sponsored Research received $861,088 in federal funding awarded June 24, 2026, through the National Institute of Allergy and Infectious Diseases (NIAID) Allergy and Infectious Diseases Research program (CFDA 93.855). The project, extending through May 31, 2031, supports research into a novel monoclonal antibody (ALT-100) targeting enampt (extracellular nicotinamide phosphoribosyl transferase) to reduce antimicrobial...
Marshall University Research Corporation received a $221,250 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 1, 2026, through June 30, 2028. The award funds research into the functional redundancy and activation mechanisms of enterococcal proteases in catheter-associated urinary tract infections (CAUTIs) caused by Enterococcus faecalis. The research will deliver scientific outputs including proteomic mapping of host protease-mediated cleavage sites on bacterial serine proteases through in vivo immunoprecipitation and liquid chromatography-mass spectrometry (LC-MS/MS) analysis, transcriptomic analysis of quorum-sensing circuit reprogramming via RNA sequencing, and quantitative analysis of biofilm formation and epithelial disruption using a murine CAUTI model with confocal microscopy. The project addresses a clinical challenge characterized by high rates of antibiotic resistance and recurrence due to biofilm formation. Deliverables will clarify how the urinary tract microenvironment activates bacterial virulence factors through host proteases and how bacterial proteases exploit host fibrinogen to drive biofilm architecture and tissue invasion. These research outputs are expected to challenge existing canonical models of protease activation and provide mechanistic insights that may inform therapeutic approaches to CAUTI prevention and treatment.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $221.3k | 7/3/26 |