Project Grant R21AI194864
- Federal Grant Award Summary Yale University received a $373,090 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 25, 2025, with a completion date of July 31, 2026. The award supports development of Modular Degraders of Extracellular Proteins (MODES), a novel therapeutic approach designed to remove pathogenic extracellular proteins from circulation. The research program...
- Federal Grant Award Summary Yale University received a $735,631 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded April 1, 2026, with completion targeted for March 31, 2031. The research focuses on investigating the origin and functional properties of CX3CR1+ neutrophils, a novel neutrophil population with distinct biological characteristics compared to canonical neutrophils....
- Federal Grant Award Summary Yale University received a $603,338 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective July 3, 2025, with a completion date of June 30, 2030. The award supports advanced structural and computational research investigating human immunodeficiency virus 1 (HIV-1) fusion mechanisms on native cell membranes. The primary deliverables include...
- Federal Grant Award Summary Yale University received a $453,629 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 8, 2025, with completion targeted for June 30, 2027. The grant supports development and application of PHAGE-SEQ, a high-throughput technology combining phage display of nanobodies (VHH recognition domains derived from camelid heavy chain-only immunoglobulins)...
- Federal Project Grant Award Summary Yale University received a $792,513 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded April 8, 2026, with a completion date of March 31, 2031. The award funds research addressing serotype re-emergence and vaccine impact in the context of next-generation pneumococcal conjugate vaccines (PCVs). The research delivers novel scientific insights...
- Federal Grant Award Summary Yale University received a $251,375 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded September 2, 2025, with a completion date of August 31, 2027. The grant supports research to identify new antigens in seronegative myasthenia gravis (SNMG), an autoimmune neuromuscular disorder characterized by the absence of detectable autoantibodies to known...
- Federal Project Grant Award Summary Yale University received a $778,828 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded April 6, 2026, with a completion date of March 31, 2031. This award supports investigator-initiated research examining novel loss-of-function gene variants in ZFYVE21 and their role in dysregulated innate immunity. The research deliverables include...
- Federal Project Grant Award Summary Yale University received a $405,585 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on July 18, 2025, with completion targeted for June 30, 2027. The grant supports the development of a multiplexed CRISPR activation and interference (CRISPRa/i) system designed to elucidate gene regulatory networks underlying T cell development in primary...
- Federal Grant Award Summary Yale University received a $3.13 million Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 25, 2025, with a completion date of June 30, 2029. The grant funds investigator-initiated biomedical research focused on elucidating the mechanisms of lymphoid-specific beta-catenin protein degradation in B-lymphoid cells. The research will characterize how B-cells...
- Federal Project Grant Award Summary Yale University received a $251,938 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded June 12, 2026, with completion targeted for May 31, 2028. The award funds research to discover and develop cell-intrinsic immunologic adjuvants designed to enhance next-generation self-amplifying RNA (saRNA) vaccines. The primary deliverable is investigation of...
Yale University received a $335,917 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 9, 2026, with completion targeted for May 31, 2028. The award funds preclinical research to develop tissue-engineered vascular grafts (TEVGs) for treating patients with obstructive vascular diseases and acute peripheral injuries who lack suitable autologous vessels for reconstruction. The research deliverables focus on creating novel, hemocompatible small-diameter vascular grafts using human induced pluripotent stem cells (hiPSCs) differentiated into vascular smooth muscle cells (VSMCs) and seeded on biodegradable scaffolds within bioreactors. The primary innovation involves endothelializing the decellularized TEVGs with hypoimmunogenic, "universal" endothelial cells to eliminate allogeneic immunorejection concerns that plagued previous acellular TEVG designs. This research addresses the critical clinical gap created by the failure of synthetic materials (expanded polytetrafluoroethylene and Dacron) in small-diameter vascular applications. The work conducted at Yale's New Haven facility will generate scientific data, bioengineered vascular graft prototypes, and methodological advances intended to support future clinical translation of immunocompatible vascular replacement solutions.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $335.9k | 6/11/26 |