Project Grant R21AI193256
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $842,888 on February 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify immunological and transcriptional factors associated with treatment outcomes in drug-susceptible tuberculosis. The recipient will conduct transcriptional profiling of whole blood to define pathways and genetic regulatory networks associated with shorter time...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded $463,601 to The Regents of the University of California, San Francisco on June 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research investigating how cytomegalovirus (CMV) infection compromises immune control of Mycobacterium tuberculosis (MTB), the pathogen causing tuberculosis. The research employs a murine co-infection...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $150,104 on January 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to explore leaderless mRNA translation in mycobacteria as a potential drug target for tuberculosis treatment. The research comprises three aims investigating how mycobacterial ribosomes translate leaderless mRNAs—transcripts lacking the 5' untranslated region and...
- The National Institute of Allergy and Infectious Diseases awarded the University of California Irvine $205,216 on July 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to discover and characterize proteins required for Mycobacterium tuberculosis heme degradation. The research aims to identify additional proteins in the MTB heme catabolism pathway beyond the known MHUD protein, which catalyzes iron release from heme. The project will investigate the fate of MHUD...
- The National Institute of Allergy and Infectious Diseases awarded Baylor College of Medicine $752,172 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct a mechanistic study of an RNA translocase via integrative multi-resolution approach. The research investigates how mycobacteria persist in the host by examining a conserved bifunctional RNA helicase and nuclease enzyme found across mycobacterium species. The enzyme is thought to promote...
- The National Institute of Allergy and Infectious Diseases awarded $1.59 million to the University of Colorado-Denver under Project Grant R01AI187511 on September 17, 2025, to support research integrating genomic architecture and tuberculosis immunity in Africa under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research generates population-level genetic data (HLA, KIR, and SNP array) on 5,000 case/control samples from multi-ancestry individuals in South Africa's...
- The National Institute of Allergy and Infectious Diseases awarded the University of California Irvine $141,712 on February 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to characterize a novel histidine phosphotransfer system involved in the virulence of Mycobacterium tuberculosis. The funded research investigates how virulence-associated dikinase (VADK) coordinates metabolism and virulence in MTB by interacting with partner proteins. The work combines...
- The National Institute of Allergy and Infectious Diseases awarded University of Massachusetts Medical School $139,968 on September 30, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the relationship between genetic variants, transcriptional responses, and Mycobacterium tuberculosis infection outcomes in macrophages derived from genetically diverse Collaborative Cross mice. The research explores how polymorphisms such as those in the STAT2 locus...
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services National Institutes of Health, awarded $427,623 to The Washington University on February 24, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research dissecting how HIV-induced immunometabolic perturbation impairs tuberculosis control in people living with HIV despite effective antiretroviral therapy and viral suppression. The research...
- The National Institute of Allergy and Infectious Diseases awarded Duke University $171,269 on November 1, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of the RGS12 locus in macrophage function. The research uses the zebrafish-Mycobacterium marinum model and human tuberculosis patient cohort datasets to examine how RGS12B regulates macrophage epithelioid transformation and granuloma bacterial containment. Preliminary data indicate that...
The National Institute of Allergy and Infectious Diseases awarded the University of California Santa Cruz $259,415 on September 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to determine the functional role of long non-coding RNAs (lncRNAs) in tuberculosis infection within macrophages. The research investigates post-transcriptional regulatory mechanisms that control innate immune response to Mycobacterium tuberculosis. The work follows preliminary screening of a lncRNA CRISPRi library engineered with an NFKB reporter gene, which identified 12 previously unreported lncRNAs required for NFKB activation. The funded project will characterize the role of conserved candidate lncRNAs in MTB infection outcomes, addressing a gap in understanding how disruption of early inflammatory responses determines whether TB is controlled or progresses to acute disease. The research employs CRISPRi technology to overcome limitations of traditional gene editing approaches for non-coding RNA targets. Work is performed in Santa Cruz, California. The period of performance runs from September 2, 2026, through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $259.4k | 9/2/26 |