This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $392,500.00 to Arizona State University to develop research projects addressing gaps in understanding mammal-virus evolutionary dynamics and zoonotic disease transmission risks. The key products and services to be delivered under this 5-year award include: Building automated tools to curate and regularly update genetic data on...
The federal Project Grant award, totaling $805,375, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to elucidate the tropism, receptor usage, and pathogenesis mechanisms of the emerging bat-derived pararubulaviruses, such as Menangle virus and Sosuga virus, which pose a potential global health threat. The research will employ a multi-pronged approach, including: Defining the...
This $563,513 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research at Arizona State University (ASU) focused on understanding the patterning, growth, and maturation of the cortical microtubules in the Toxoplasma parasite. The research aims to explore the initiation of microtubule patterning, as well as the growth and maturation of the microtubule array in this...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $840,000 to Louisiana State University Health Sciences Center New Orleans to develop a rabbit model for myeloperoxidase (MPO) deficiency. The overarching goal is to establish an accurate animal model that replicates human MPO deficiency in both infection and inflammatory diseases, in order to advance the...
This federal Project Grant award of $128,052 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research on the Rift Valley Fever Virus (RVFV) at Virginia Polytechnic Institute & State University (Virginia Tech). The project aims to define the molecular mechanism by which the RVFV nonstructural small (NSS) protein interacts with autophagy proteins called LC3 family members, and to...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $406,450.00 to support research on the continuous in vitro culture and genetics of the Plasmodium vivax malaria parasite. The key objectives are to: 1) optimize the production of reticulocytes (young red blood cells) to support continuous P. vivax culture, 2) optimize culture conditions using a bespoke...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $125,160 to support research into a novel bacterial immune system. The project aims to use cutting-edge cryogenic electron microscopy techniques to define the structure and assembly mechanisms of a two-component complex, denoted as A and B, which is believed to play a role in anti-phage defense in bacteria. The...
This Federal Project Grant award of $1,447,376.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund a multidisciplinary investigation into the dynamics of viruses in wild bat populations. The research aims to elucidate how bat behavior and virus shedding patterns shape exposure risk for humans and domestic animals, as well as how bat displacements and other perturbations affect viral...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,780,622 to the University of Wisconsin System for research on the pathogenic bacterium Listeria monocytogenes. The research aims to identify and characterize genes required for L. monocytogenes to survive and thrive within the cytosol (interior) of host cells, a key virulence mechanism for this foodborne pathogen....
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $221,105 to the University of Arkansas for Medical Sciences (UAMS) from May 1, 2025 to April 30, 2027. The award will fund research to investigate how the human APOBEC3 enzymes impact the evolution of poxviruses, such as Monkeypox virus. The project aims to: 1) examine the biochemical activities of APOBEC3...