This $545,630 Project Grant award under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) from the National Institute of Biomedical Imaging and Bioengineering aims to develop bispecific antibodies fused to the cytokine IL-2, referred to as IL-2 immunocytokines. The key goal is to create a non-invasive and long-lived method for delivering these cytokines to the central nervous system (CNS) to selectively induce regulatory T cells...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports the development of broadly neutralizing human monoclonal antibodies (bnAbs) against Henipaviruses. The $809,614 award aims to overcome the limitations of current narrowly focused vaccine and antibody candidates by designing novel immunogens to elicit bnAbs effective against a wide range of Henipaviruses,...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of cells, antigens, and antibodies in controlling virus infections through antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytolysis (CDC). The $318,085 award, running from December 2024 to November 2029, aims...
This is a Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) for $2,694,884. The grant supports research to characterize the disruption of the brain endothelial barrier during cerebral malaria, a serious complication of Plasmodium falciparum infection. The research aims to define the role of natural hemozoin, a byproduct of the malaria parasite, in disrupting the blood-brain...
This $432,250 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop innovative single-cell techniques to gain unprecedented insight into West Nile virus (WNV) infection of the lymphatic system and spleen. The research team at Emory University will use these advanced analytical methods to identify the key cellular targets of WNV infection and map the molecular...
This $737,761 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to enhance the efficacy of an HIV vaccine by promoting durable CD4 T follicular helper (Tfh) cell immunity. The primary objective is to induce robust Tfh1 cells, which are essential for generating vigorous B cell activity and persistent antibody responses within germinal centers. The research approach involves...
This Project Grant award for $769,115 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to advance the understanding of how neurotropic viruses, such as flaviviruses and alphaviruses, can directly enter the central nervous system through newly discovered meningeal structures called arachnoid cuff exit (ACE) points. The highly collaborative research project between the Diamond and Kipnis laboratories at...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $199,584 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Albert Einstein College of Medicine in Bronx, New York. The purpose of this 4-year grant, starting on July 1, 2024, is to identify and design broadly acting antibodies targeting the conserved S2 subunit of the betacoronavirus spike protein. The research aims to develop novel therapeutics that can provide broad...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under CFDA 93.855 Allergy and Infectious Diseases Research program, provides $1,517,437.00 to Emory University to conduct research on the epigenetic regulation of early B cell differentiation and the pathways that control B cell fate choices. The research aims to determine the transcriptional and epigenetic mechanisms that govern antibody-secreting cell formation versus memory B cell...
This federal Project Grant award, valued at $502,075.00 and issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to investigate the impact of mucosal adjuvanted vaccines on virus transmission in preclinical animal models for SARS-CoV-2 and influenza virus infection. The research will compare the protection provided by intranasal mucosal adjuvanted vaccination versus intramuscular parenteral...