Project Grant R01AI187016

Award Date 8/1/24
Completion Date 6/30/29
Dollars Obligated $738K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Pittsburgh, PA 15222, USA
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The federal Project Grant award R01AI187016 for $737,761.00, awarded on August 1, 2024 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to enhance HIV prevention through a vaccine approach that promotes durable immunity. The key objectives are to induce robust CD4 T follicular helper (TFH) cells, which are essential for vigorous B cell activity within germinal centers, to facilitate the differentiation of germinal center B cells into plasma cells and generate persistent antibodies. The research will examine whether a vaccine platform tailored to promote TFH1 cell differentiation, in combination with trimeric Env antigens, can enhance Env antibody durability and increase protective efficacy. The project involves comprehensive immune analyses, cellular immunology, and serological assessments in rhesus macaques, with the goal of innovating HIV vaccine design by integrating strategies to induce optimized TFH cells into broadly neutralizing antibody-inducing platforms.

The project includes a sub-award to Emory University, which will contribute its expertise in TFH biology, humoral immunity, and bioinformatics to support the collaborative research efforts.

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