The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $269,054 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of California, Merced to investigate novel susceptibility mechanisms to Toxoplasma gondii, a widespread parasitic infection. The research aims to leverage the Collaborative Cross mouse panel and parasite genetics to identify host genes and host-parasite interactions that govern disease outcomes from low-virulence T. gondii...
This $849,500 federal Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The objective of this 2-year project is to determine how the TREM2 receptor functions in human innate immunity and in protection against Toxoplasma gondii infection in vivo. The research will examine the signal transduction pathways and immune responses activated by TREM2 in human monocytic cells...
This $186,451 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA Program 93.855 Allergy and Infectious Diseases Research supports research to characterize the molecular mechanism of CD4+ T cell migration to the brain during HIV/AIDS-associated cryptococcal immune reconstitution inflammatory syndrome (IRIS). The key objectives are to: 1) determine whether TNF-α signaling mediates CD4+ T cell migration to the brain in a cell-intrinsic manner...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $211,950 in funding to the University of California, Irvine to investigate the role of nucleic acid-containing immune complexes in sustaining immune activation and endothelial dysfunction in people living with HIV (PLWH) who are on antiretroviral therapy. The research aims to measure the inflammatory response to...
This $215,860 federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports a mid-career investigator's research portfolio to improve the diagnosis, treatment, and prevention of HIV-related central nervous system (CNS) infections. The key products and services delivered include: Enrolling a prospective cohort of HIV-positive individuals with meningitis to enable...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $870,800 to study the role of memory T cells in the brains of mice with "normalized" immune systems. The goal is to understand how repeated microbial exposure impacts the generation of brain-surveilling T cells and their interactions with other immune cells, such as dendritic cells, in the central...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $176,537 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the CAL Poly Pomona Foundation Inc. The project aims to uncover the innate immune responses and mechanisms involved in how neutrophils use reactive oxygen species (ROS) to control acute Toxoplasma gondii infection. Specifically, the project will: 1) Determine the cellular events required to induce ROS in T....
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Regents of the University of California, San Francisco (UCSF) in the amount of $285,816. The objective of this 3-year grant, with a project period from September 12, 2024 to October 31, 2027, is to enhance the understanding of ADP-ribosylation (ADPR) in the context of HIV-1 latency and reactivation. The research aims to identify...
The National Institute of Allergy and Infectious Diseases (NIAID) has awarded a $781,367 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Weill Medical College of Cornell University. The grant, awarded on January 25, 2024, will support research to define and maximize the impact of CD8+ T-cell selection on the landscape of HIV integration sites. The goal is to optimize strategies for eradicating the persistent reservoir of HIV-infected cells and achieve...
This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to investigate the in vivo innate immune response to HIV-1 infection. The $231,752 grant, awarded to the Fred Hutchinson Cancer Center in Seattle, WA, will leverage the MISTRG "humanized mouse" model to study the cellular sources and functional roles of cytokines released during...