The National Institute of Allergy and Infectious Diseases (NIAID) has awarded a $276,450 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Salk Institute for Biological Studies in La Jolla, California. The grant will fund a 2-year research project to investigate the role of the PPARD/CIITA/MHCII axis in regulating regulatory T cell (Treg) function and its implications for tumor immunity. The study aims to elucidate the molecular mechanisms by which MHCII expression in Tregs enhances their suppressive function, and to characterize the in vivo consequences of modulating this pathway in mouse cancer models. The research outcomes are expected to reveal new insights into Treg-mediated immune regulation in the tumor microenvironment and provide evidence supporting the development of therapeutics targeting the PPARD and CIITA/MHCII pathways to enhance anti-tumor immunity.
Generated 3/18/25, 4:45 AM