This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $558,501 to Albert Einstein College of Medicine to conduct research on the Crimean-Congo Hemorrhagic Fever Virus (CCHFV). The overarching goal is to address critical gaps in understanding the architecture, assembly, and functions of the CCHFV glycoprotein components and complexes, and their roles in virion assembly, entry, host cell subversion, and disease pathogenesis. The collaborative research team, which includes experts from multiple institutions, aims to deliver high-resolution structural analyses of CCHFV glycoprotein complexes, discover novel human monoclonal antibodies, elucidate mechanisms of CCHFV assembly and entry, and uncover entry-independent pathogenic mechanisms mediated by the CCHFV GP38 protein. This research is expected to identify viral vulnerabilities for developing much-needed medical countermeasures against this priority pathogen. The project also includes a $31,259 sub-award to the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. to support the overall research objectives.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $558.5k | 8/15/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
31259AS | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Project Grant R01AI185073 | $115.2k | 9/26/24 |