The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $769,201 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Massachusetts Medical School (UMass Medical) to support research aimed at combating parasitic nematode resistance. The research will focus on discovering optimal combinations of Bacillus thuringiensis (Bt) crystal proteins and small molecule anthelmintic drugs, such as albendazole, ivermectin, and...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,827,805.00 to The Trustees of the University of Pennsylvania to conduct research on neuro-immune mechanisms against skin-penetrating helminths. The overarching objective is to understand how sensory neuron-antigen presenting cell interactions control host protection and interleukin-33 (IL-33) expression,...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $364,324 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Johns Hopkins University. The grant supports research to identify the genetic mechanisms underlying resistance to the anthelmintic drug emodepside, which is used to treat parasitic nematode infections in humans and livestock. The research will use the model organism Caenorhabditis elegans to characterize gene variants...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $226,738 to Creighton University to conduct research on enhancing the efficacy of the anthelmintic drug emodepside against filarial nematode infections, such as lymphatic filariasis. The key research objectives are: 1) Characterizing the pharmacology of endogenous SLO-1/2 potassium channels in the nematode...
This $696,544 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) aims to leverage new CRISPR-based genetic tools and biophysical assays to investigate the molecular mechanisms underlying the ventral disc contractile attachment process of the Giardia intestinal parasite. The research will focus on evaluating the contributions of key disc structural elements to the forces and modes of disc contraction that...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $369,431.00 to the University of Wisconsin-Eau Claire to conduct research on the molecular determinants and behavioral characteristics of schistosome miracidia host-seeking. The project aims to quantitatively describe miracidia behaviors, extract behavioral fingerprints, and screen environmental stimuli and small...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $155,686 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Baylor College of Medicine to conduct a prospective study on optimizing screening and diagnostic strategies for Strongyloides stercoralis infection, a parasitic disease that disproportionately impacts socioeconomically disadvantaged populations in the U.S. The two-year grant, running from February 2025 through January 2027,...
The federal Project Grant award, totaling $451,292.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to uncover neuronal mechanisms orchestrating metabolic adaptations to bacterial infections, with a focus on delineating the pivotal role of the brain-liver axis in modulating metabolic responses. The research seeks to identify neurocircuits in the hypothalamus that...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $218,767 to the University of Washington to conduct a single-cell transcriptional atlas of Giardia encystation. The research aims to build an atlas of gene expression during the Giardia cell cycle (Aim 1) and differentiation into dormant cyst forms (Aim 2). This research is critical for understanding the regulation...
This federal Project Grant award of $787,043 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to elucidate the evolutionary history of symbiotic associations between the Mucoromycotina fungi and their endosymbiotic bacteria. The primary objectives are to gain insights into population-level processes that govern these fungal-bacterial symbioses, including the role of epigenetic reprogramming via...